Abstract

The goals of this amended program project application are directed towards the immunobiology of normal and neoplastic lymphocytes, the role of the major histocompatibility complex (MHC) in immune regulation, and the cytogenetics and biology of human lymphoid tumors. Specifically, the component project deals with studies of (1) the function and specificity of human and murine T cells, (2) the control by MHC gene products of replication of leukemogenic virus in cultured cell lines, and (3) the genetic and biologic changes associated with human lymphocytic leukemia. This program is a component of the University of Pennsylvania Cancer Center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA015822-17
Application #
3092680
Study Section
Cancer Special Program Advisory Committee (CAK)
Project Start
1979-07-01
Project End
1993-03-31
Budget Start
1991-06-01
Budget End
1993-03-31
Support Year
17
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Fox, F E; Ford, H C; Douglas, R et al. (1993) Evidence that TGF-beta can inhibit human T-lymphocyte proliferation through paracrine and autocrine mechanisms. Cell Immunol 150:45-58
Fox, F E; Capocasale, R J; Ford, H C et al. (1992) Transforming growth factor-beta inhibits human T-cell proliferation through multiple targets. Lymphokine Cytokine Res 11:299-305
Abrams, J T; Lessin, S R; Ghosh, S K et al. (1991) Malignant and nonmalignant T cell lines from human T cell lymphotropic virus type I-negative patients with Sezary syndrome. J Immunol 146:1455-62
Modiano, J F; Kokai, Y; Weiner, D B et al. (1991) Progesterone augments proliferation induced by epidermal growth factor in a feline mammary adenocarcinoma cell line. J Cell Biochem 45:196-206
Abrams, J T; Lessin, S; Ghosh, S K et al. (1991) A clonal CD4-positive T-cell line established from the blood of a patient with Sezary syndrome. J Invest Dermatol 96:31-7
Kesavan, P; Mukhopadhayay, S; Murphy, S et al. (1991) Thyroid hormone decreases the expression of epidermal growth factor receptor. J Biol Chem 266:10282-6
Modiano, J F; Kolp, R; Lamb, R J et al. (1991) Protein kinase C regulates both production and secretion of interleukin 2. J Biol Chem 266:10552-61
Khire, J; Das, M (1990) EGF stimulates the processing and export of a secreted form of EGF receptor. FEBS Lett 272:69-72
Das, M; Kesavan, P; Khire, J (1990) Control of expression and maturation of epidermal growth factor receptor. J Cell Biochem 44:61-8
Das, M; Khire, J; Kesavan, P (1990) Maturation and externalization of EGF-receptor: a cell-surface located oncoprotein. Indian J Biochem Biophys 27:438-42

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