We propose a multi-faceted program to investigate the molecular basis o the transformation of cells by DNA viruses. Specific programs include genetic and molecular approaches to the analysis of host proteins interacting with BPV E5 and ras oncogenes, and host proteins determining the differential susceptibility of transformed cells to parvovirus infection. Other projects concern the analysis of transforming genes of EBV and of novel methods by which herpesviruses may modulate host cell gene expression, studies of the interaction between oncogenes and host DNA sequences, and an approach to defining cell pathways and the action of oncogenes in transforming keratinocytes and melanocytes and the possible modulation of the transformed properties of individual cells by surrounding normal cells. A core provides administrative support and support for common equipment and facilities. This program represents a Yale Medical School that has been in operation for fourteen years.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA016038-17
Application #
3092689
Study Section
Special Emphasis Panel (SRC (N1))
Project Start
1979-05-01
Project End
1994-04-30
Budget Start
1990-05-01
Budget End
1991-04-30
Support Year
17
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
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Inoue, Takamasa; Zhang, Pengwei; Zhang, Wei et al. (2018) ?-Secretase promotes membrane insertion of the human papillomavirus L2 capsid protein during virus infection. J Cell Biol 217:3545-3559
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Singh, Gatikrushna; Fritz, Sarah M; Ranji, Arnaz et al. (2017) Isolation of Cognate RNA-protein Complexes from Cells Using Oligonucleotide-directed Elution. J Vis Exp :
Martinez, Ivan; Hayes, Karen E; Barr, Jamie A et al. (2017) An Exportin-1-dependent microRNA biogenesis pathway during human cell quiescence. Proc Natl Acad Sci U S A 114:E4961-E4970
Lee, Nara; Yario, Therese A; Gao, Jessica S et al. (2016) EBV noncoding RNA EBER2 interacts with host RNA-binding proteins to regulate viral gene expression. Proc Natl Acad Sci U S A 113:3221-6
DiMaio, Daniel (2016) Thank You, Edward. Merci, Louis. PLoS Pathog 12:e1005320

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