Abstract

This is a broadly based program in which gene expression and genome replication in both prokaryotes and eukaryotes is studied. Cells infected with RNA and DNA tumor viruses are used frequently throughout the work. In addition the biosynthesis of proteins in cell membranes is studied. All of the studies are carried by the molecular level involving DNA, RNA and protein sequencing and levels of interactions and regulations between various virus specific and cell macromolecules explored. The implications for all of these results in cancer biology underlies the design of many experiments.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA018213-12
Application #
3092771
Study Section
Cancer Special Program Advisory Committee (CAK)
Project Start
1976-06-30
Project End
1989-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
12
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Rockefeller University
Department
Type
Graduate Schools
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Murphy, J S; Tamm, I (1991) Effects of interferon-beta on the translocation rate and stationary time in human fibroblasts in culture. Cell Motil Cytoskeleton 19:99-108
Russel, M; Model, P; Holmgren, A (1990) Thioredoxin or glutaredoxin in Escherichia coli is essential for sulfate reduction but not for deoxyribonucleotide synthesis. J Bacteriol 172:1923-9
Dorai, T; Wang, L H (1990) An alternative non-tyrosine protein kinase product of the c-src gene in chicken skeletal muscle. Mol Cell Biol 10:4068-79
Brissette, J L; Russel, M (1990) Secretion and membrane integration of a filamentous phage-encoded morphogenetic protein. J Mol Biol 211:565-80
Roos, D S; Duchala, C S; Stephensen, C B et al. (1990) Control of virus-induced cell fusion by host cell lipid composition. Virology 175:345-57
Sudol, M; Kuo, C F; Shigemitsu, L et al. (1989) Expression of the yes proto-oncogene in cerebellar Purkinje cells. Mol Cell Biol 9:4545-9
Xanthopoulos, K G; Mirkovitch, J; Friedman, J M et al. (1989) The mouse Cebp gene encoding a DNA-binding protein is polymorphic and is located on chromosome 7. Cytogenet Cell Genet 50:174-5
Vales, L D; Darnell Jr, J E (1989) Promoter occlusion prevents transcription of adenovirus polypeptide IX mRNA until after DNA replication. Genes Dev 3:49-59
Costa, R H; Grayson, D R; Darnell Jr, J E (1989) Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes. Mol Cell Biol 9:1415-25
Xanthopoulos, K G; Mirkovitch, J; Decker, T et al. (1989) Cell-specific transcriptional control of the mouse DNA-binding protein mC/EBP. Proc Natl Acad Sci U S A 86:4117-21

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