Over the past years the Division of Oncology at the University of Washington has been involved in a continuing program of marrow transplantation for the treatment of patients with advanced, otherwise fatal malignant and non-malignant hemopoietic diseases. A number of grafted patients have become long-term survivors without recurrence of their original disease and without occurrence of graft-versus-host disease. Many patients, however, have died from recurrent disease or, more frequently, from complications related to the transplant. Further improvement in clinical marrow grafting hinges upon progress in and better understanding of at least three major areas of study: 1) recovery of immunologic reactivity in marrow graft recipients, 2) understanding of mechanisms of stable graft-host tolerance and of graft-versus-host disease, 3) methods of recognizing and overcoming sensitization of a marrow graft recipient by preceding blood transfusions. It is the objective of this proposal to conduct an immunologic investigation into those three areas of study.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA018221-11
Application #
3092778
Study Section
Clinical Cancer Program Project Review Committee (CCP)
Project Start
1978-09-01
Project End
1986-11-30
Budget Start
1985-12-01
Budget End
1986-11-30
Support Year
11
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
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Tseng, Li-Hui; Storer, Barry; Petersdorf, Effie et al. (2009) IL10 and IL10 receptor gene variation and outcomes after unrelated and related hematopoietic cell transplantation. Transplantation 87:704-10
Bensinger, W I (2009) Role of autologous and allogeneic stem cell transplantation in myeloma. Leukemia 23:442-8
Bensinger, William (2008) Stem-cell transplantation for multiple myeloma in the era of novel drugs. J Clin Oncol 26:480-92
Storek, Jan (2008) Immunological reconstitution after hematopoietic cell transplantation - its relation to the contents of the graft. Expert Opin Biol Ther 8:583-97
Bensinger, William I (2007) Is there still a role for allogeneic stem-cell transplantation in multiple myeloma? Best Pract Res Clin Haematol 20:783-95
Carpenter, Paul A; Hoffmeister, Paul; Chesnut 3rd, Charles H et al. (2007) Bisphosphonate therapy for reduced bone mineral density in children with chronic graft-versus-host disease. Biol Blood Marrow Transplant 13:683-90
Bensinger, William I (2007) Reduced intensity allogeneic stem cell transplantation in multiple myeloma. Front Biosci 12:4384-92
Zaucha, Renata E; Buckner, Dean C; Barnett, Todd et al. (2006) Modified total body irradiation as a planned second high-dose therapy with stem cell infusion for patients with bone-based malignancies. Int J Radiat Oncol Biol Phys 64:227-34
Alkindi, S; Deeg, J H; Flowers, M E D (2006) Recovery of normal autologous myelopoiesis after graft rejection following allogeneic bone marrow transplant for agnogenic myeloid metaplasia. Clin Lab Haematol 28:134-7

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