Abstract

Project I concerns the functional organization of the herpes simplex and Epstein-Barr virus genomes. The objectives of this project are to map and define the viral genes with specific emphasis on genes responsible for transformation of cells and for the maintenance of the transformed state. Project II concerns the expression of HEL 12 retrovirus. The objectives of this project are to characterize the gene product specified by this virus in human tissues by molecular probes and by immunologic approaches.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA019264-10
Application #
3092821
Study Section
Cancer Special Program Advisory Committee (CAK)
Project Start
1976-06-30
Project End
1989-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
10
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Chicago
Department
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Chou, J; Roizman, B (1989) Characterization of DNA sequence-common and sequence-specific proteins binding to cis-acting sites for cleavage of the terminal a sequence of the herpes simplex virus 1 genome. J Virol 63:1059-68
Roller, R J; McCormick, A L; Roizman, B (1989) Cellular proteins specifically bind single- and double-stranded DNA and RNA from the initiation site of a transcript that crosses the origin of DNA replication of herpes simplex virus 1. Proc Natl Acad Sci U S A 86:6518-22
Fuller, A O; Santos, R E; Spear, P G (1989) Neutralizing antibodies specific for glycoprotein H of herpes simplex virus permit viral attachment to cells but prevent penetration. J Virol 63:3435-43
Johnson, R M; Spear, P G (1989) Herpes simplex virus glycoprotein D mediates interference with herpes simplex virus infection. J Virol 63:819-27
Kwong, A D; Frenkel, N (1989) The herpes simplex virus virion host shutoff function. J Virol 63:4834-9
WuDunn, D; Spear, P G (1989) Initial interaction of herpes simplex virus with cells is binding to heparan sulfate. J Virol 63:52-8
Kwong, A D; Kruper, J A; Frenkel, N (1988) Herpes simplex virus virion host shutoff function. J Virol 62:912-21
Michael, N; Spector, D; Mavromara-Nazos, P et al. (1988) The DNA-binding properties of the major regulatory protein alpha 4 of herpes simplex viruses. Science 239:1531-4
Meignier, B; Longnecker, R; Mavromara-Nazos, P et al. (1988) Virulence of and establishment of latency by genetically engineered deletion mutants of herpes simplex virus 1. Virology 162:251-4
Roizman, B; Kristie, T; McKnight, J L et al. (1988) The trans-activation of herpes simplex virus gene expression: comparison of two factors and their cis sites. Biochimie 70:1031-43

Showing the most recent 10 out of 88 publications