An integrated, multidisciplinary laboratory and clinical investigation is underway at the Sidney Farber Cancer Institute. This includes projects ranging from clinical trials, clinical pharmacology, cell biology studies of clinical materials, immunology, epidemilogy, pediatric oncology, microbiology, blood component research, cytogenetics, and biostatistics. We are fortunate at this center, and through collaboration with adjacent institutions, to have a broad base of basic and bridging sciences as they relate to tumor biology. This clinical center grant provides the glue for integrated clinical research, as well as for support for the interaction between clinical and basic scientists when appropriate, particularly with respect to application to the clinic.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA019589-10
Application #
3092849
Study Section
Cancer Therapeutics Program Project Review Committee (CTR)
Project Start
1976-06-30
Project End
1990-04-30
Budget Start
1986-05-01
Budget End
1987-04-30
Support Year
10
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
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Chen, G; Wright, J E; Rosowsky, A (1995) Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells. Mol Pharmacol 48:758-65
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