Abstract

An integrated, multidisciplinary laboratory and clinical investigation is underway at the Sidney Farber Cancer Institute. This includes projects ranging from clinical trials, clinical pharmacology, cell biology studies of clinical materials, immunology, epidemilogy, pediatric oncology, microbiology, blood component research, cytogenetics, and biostatistics. We are fortunate at this center, and through collaboration with adjacent institutions, to have a broad base of basic and bridging sciences as they relate to tumor biology. This clinical center grant provides the glue for integrated clinical research, as well as for support for the interaction between clinical and basic scientists when appropriate, particularly with respect to application to the clinic.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA019589-10
Application #
3092849
Study Section
Cancer Therapeutics Program Project Review Committee (CTR)
Project Start
1976-06-30
Project End
1990-04-30
Budget Start
1986-05-01
Budget End
1987-04-30
Support Year
10
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Rosowsky, A; Vaidya, C M; Bader, H et al. (1997) Analogues of N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523) modified in the side chain: synthesis and biological evaluation. J Med Chem 40:286-99
Dreyfuss, A I; Clark, J R; Norris, C M et al. (1996) Docetaxel: an active drug for squamous cell carcinoma of the head and neck. J Clin Oncol 14:1672-8
Teicher, B A; Holden, S A; Ara, G et al. (1996) Comparison of several antiangiogenic regimens alone and with cytotoxic therapies in the Lewis lung carcinoma. Cancer Chemother Pharmacol 38:169-77
Bharti, A K; Olson, M O; Kufe, D W et al. (1996) Identification of a nucleolin binding site in human topoisomerase I. J Biol Chem 271:1993-7
Matherly, L H; Taub, J W; Ravindranath, Y et al. (1995) Elevated dihydrofolate reductase and impaired methotrexate transport as elements in methotrexate resistance in childhood acute lymphoblastic leukemia. Blood 85:500-9
Robinson, M F; Dupuis, N P; Kusumoto, T et al. (1995) Increased tumor oxygenation and radiation sensitivity in two rat tumors by a hemoglobin-based, oxygen-carrying preparation. Artif Cells Blood Substit Immobil Biotechnol 23:431-8
Teicher, B A; Dupuis, N P; Emi, Y et al. (1995) Increased efficacy of chemo- and radio-therapy by a hemoglobin solution in the 9L gliosarcoma. In Vivo 9:11-8
Shapiro, C L; Dezube, B J; Tretyakov, O et al. (1995) Dose escalation of N,N',N""-triethylenethiophosphoramide combined with pentoxifylline for advanced breast cancer. Clin Cancer Res 1:791-6
Shapiro, G I; Edwards, C D; Kobzik, L et al. (1995) Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines. Cancer Res 55:505-9
Chen, G; Wright, J E; Rosowsky, A (1995) Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells. Mol Pharmacol 48:758-65

Showing the most recent 10 out of 145 publications