Abstract

An integrated, multidisciplinary laboratory and clinical investigation is underway at the Sidney Farber Cancer Institute. This includes projects ranging from clinical trials, clinical pharmacology, cell biology studies of clinical materials, immunology, epidemilogy, pediatric oncology, microbiology, blood component research, cytogenetics, and biostatistics. We are fortunate at this center, and through collaboration with adjacent institutions, to have a broad base of basic and bridging sciences as they relate to tumor biology. This clinical center grant provides the glue for integrated clinical research, as well as for support for the interaction between clinical and basic scientists when appropriate, particularly with respect to application to the clinic.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA019589-13
Application #
3092852
Study Section
Cancer Therapeutics Program Project Review Committee (CTR)
Project Start
1976-06-30
Project End
1991-04-30
Budget Start
1989-05-01
Budget End
1991-04-30
Support Year
13
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Rosowsky, A; Vaidya, C M; Bader, H et al. (1997) Analogues of N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523) modified in the side chain: synthesis and biological evaluation. J Med Chem 40:286-99
Dreyfuss, A I; Clark, J R; Norris, C M et al. (1996) Docetaxel: an active drug for squamous cell carcinoma of the head and neck. J Clin Oncol 14:1672-8
Teicher, B A; Holden, S A; Ara, G et al. (1996) Comparison of several antiangiogenic regimens alone and with cytotoxic therapies in the Lewis lung carcinoma. Cancer Chemother Pharmacol 38:169-77
Bharti, A K; Olson, M O; Kufe, D W et al. (1996) Identification of a nucleolin binding site in human topoisomerase I. J Biol Chem 271:1993-7
Teicher, B A; Dupuis, N P; Robinson, M F et al. (1995) Antiangiogenic treatment (TNP-470/minocycline) increases tissue levels of anticancer drugs in mice bearing Lewis lung carcinoma. Oncol Res 7:237-43
Dupuis, N P; Kusumoto, T; Robinson, M F et al. (1995) Restoration of tumor oxygenation after cytotoxic therapy by a perflubron emulsion/carbogen breathing. Artif Cells Blood Substit Immobil Biotechnol 23:423-9
Lee, C; Wu, S S; Chen, L B (1995) Photosensitization by 3,3'-dihexyloxacarbocyanine iodide: specific disruption of microtubules and inactivation of organelle motility. Cancer Res 55:2063-9
Wright, J E; Pardo, M; Sayeed-Shah, U et al. (1995) Leucovorin and folic acid regimens for selective expansion of murine 5,10-methylenetetrahydrofolate pools. Biochem Pharmacol 49:677-85
Matherly, L H; Taub, J W; Ravindranath, Y et al. (1995) Elevated dihydrofolate reductase and impaired methotrexate transport as elements in methotrexate resistance in childhood acute lymphoblastic leukemia. Blood 85:500-9
Robinson, M F; Dupuis, N P; Kusumoto, T et al. (1995) Increased tumor oxygenation and radiation sensitivity in two rat tumors by a hemoglobin-based, oxygen-carrying preparation. Artif Cells Blood Substit Immobil Biotechnol 23:431-8

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