Abstract

The ultimate objective of this program is cure of children with leukemia. The program is a coordinated effort of therapy and study including: therapeutic trials; studies of biology and pathogenesis; and studies of effects of leukemia and therapy on normal tissues. The program consists of a core section and 7 interrelated projects: the core section provides for resource personnel, patient costs, leukemia cell profile studies, biostatistics and a patient data base to be used by virtually all projects. The projects are: (1) primary therapy of acute lymphocytic leukemia; (2) primary therapy of acute nonlymphocytic leukemia; (4) leukemia cell kinetics; (5) studies of in vitro growth of normal and leukemic marrow; (6) studies of hemopoietic effects of leukemia in animals; and (7) late effects of childhood leukemia. All projects except number 6 involve patients or patient materials. All projects have the same ultimate objective through a wide variety of disciplines. The organizational structure provides the means for a unified and coordinated effort.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA020180-09
Application #
3092864
Study Section
Cancer Therapeutics Program Project Review Committee (CTR)
Project Start
1977-09-01
Project End
1987-07-31
Budget Start
1986-05-01
Budget End
1987-07-31
Support Year
9
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105

  Publications

Pieters, Rob; Hunger, Stephen P; Boos, Joachim et al. (2011) L-asparaginase treatment in acute lymphoblastic leukemia: a focus on Erwinia asparaginase. Cancer 117:238-49
Kaste, Sue C (2011) Imaging pediatric bone sarcomas. Radiol Clin North Am 49:749-65, vi-vii
Kaste, Sue C; Waszilycsak, George L; McCarville, M Beth et al. (2010) Estimation of potential excess cancer incidence in pediatric 201Tl imaging. AJR Am J Roentgenol 194:245-9
Kaste, S C; Thomas, N A; Rai, S N et al. (2009) Asymptomatic kidney stones in long-term survivors of childhood acute lymphoblastic leukemia. Leukemia 23:104-8
Kaste, Sue C; Metzger, Monika L; Minhas, Anum et al. (2009) Pediatric Hodgkin lymphoma survivors at negligible risk for significant bone mineral density deficits. Pediatr Blood Cancer 52:516-21
Marchese, Victoria G; Connolly, Barbara H; Able, Colleen et al. (2008) Relationships among severity of osteonecrosis, pain, range of motion, and functional mobility in children, adolescents, and young adults with acute lymphoblastic leukemia. Phys Ther 88:341-50
Rai, Shesh N; Hudson, Melissa M; McCammon, Elizabeth et al. (2008) Implementing an intervention to improve bone mineral density in survivors of childhood acute lymphoblastic leukemia: BONEII, a prospective placebo-controlled double-blind randomized interventional longitudinal study design. Contemp Clin Trials 29:711-9
Martin, Mary Beth; Li, Chin-Shang; Rowland, Christopher C et al. (2008) Correlation of bone age, dental age, and chronological age in survivors of childhood acute lymphoblastic leukaemia. Int J Paediatr Dent 18:217-23
Kaste, Sue C; Ahn, Hyunah; Liu, Tiebin et al. (2008) Bone mineral density deficits in pediatric patients treated for sarcoma. Pediatr Blood Cancer 50:1032-8
Kaste, Sue C (2008) Skeletal toxicities of treatment in children with cancer. Pediatr Blood Cancer 50:469-73;discussion 486

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