Abstract

The objective of this program is to understand the genetic control of malignancy in human cancer cells and the mechanisms of malignant transformation by oncogenic viruses through genetic, immunological and biochemical approaches. The backgrounds in somatic cell genetics, tumor virology, immunology, molecular biology and biochemistry of the investigators involved in this program will be exploited to gain insight into the mechanisms of malignant transformation and into the processes leading to the expression of malignancy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA021124-10
Application #
3092938
Study Section
Cancer Special Program Advisory Committee (CAK)
Project Start
1977-09-01
Project End
1987-11-30
Budget Start
1986-12-01
Budget End
1987-11-30
Support Year
10
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Wistar Institute
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Russell, John P; Engiles, Julie B; Rothstein, Jay L (2004) Proinflammatory mediators and genetic background in oncogene mediated tumor progression. J Immunol 172:4059-67
Powell Jr, Daniel J; Eisenlohr, Laurence C; Rothstein, Jay L (2003) A thyroid tumor-specific antigen formed by the fusion of two self proteins. J Immunol 170:861-9
Cornetta, Anthony J; Russell, John P; Cunnane, Mary et al. (2002) Cyclooxygenase-2 expression in human thyroid carcinoma and Hashimoto's thyroiditis. Laryngoscope 112:238-42
Zanesi, N; Fidanza, V; Fong, L Y et al. (2001) The tumor spectrum in FHIT-deficient mice. Proc Natl Acad Sci U S A 98:10250-5
Podolski, J; Byrski, T; Zajaczek, S et al. (2001) Characterization of a familial RCC-associated t(2;3)(q33;q21) chromosome translocation. J Hum Genet 46:685-93
Druck, T; Podolski, J; Byrski, T et al. (2001) The DIRC1 gene at chromosome 2q33 spans a familial RCC-associated t(2;3)(q33;q21) chromosome translocation. J Hum Genet 46:583-9
Powell Jr, D J; Russell, J P; Li, G et al. (2001) Altered gene expression in immunogenic poorly differentiated thyroid carcinomas from RET/PTC3p53-/- mice. Oncogene 20:3235-46
Daheron, L; Zenz, T; Siracusa, L D et al. (2001) Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity. Nucleic Acids Res 29:1308-16
Falvella, F S; Menegola, E; Giavini, E et al. (2000) Expression of Fhit protein during mouse development. Anat Rec 260:208-11
Russell, J P; Powell, D J; Cunnane, M et al. (2000) The TRK-T1 fusion protein induces neoplastic transformation of thyroid epithelium. Oncogene 19:5729-35

Showing the most recent 10 out of 209 publications