Abstract

This program project proposal Virology and Genetics of Cancer focuses on the use of molecular genetic techniques to investigate the role of viral and cellular oncogenes in the pathogenesis and biology of human cancer. It also addresses the question of how specific oncogenes inserted in the appropriate retrovirus vectors may affect the differentiation program of stem cells. As a result of the previous studies on the expression of tumor associated antigens on gastrointestinal tumors and on the anti-tumor action of monoclonal antibodies directed against antigens expressed on human cells, we also propose new immunotherapeutic approaches to the treatment of human cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA021124-13
Application #
3092940
Study Section
Cancer Special Program Advisory Committee (CAK)
Project Start
1977-09-01
Project End
1992-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
13
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Wistar Institute
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Russell, John P; Engiles, Julie B; Rothstein, Jay L (2004) Proinflammatory mediators and genetic background in oncogene mediated tumor progression. J Immunol 172:4059-67
Powell Jr, Daniel J; Eisenlohr, Laurence C; Rothstein, Jay L (2003) A thyroid tumor-specific antigen formed by the fusion of two self proteins. J Immunol 170:861-9
Cornetta, Anthony J; Russell, John P; Cunnane, Mary et al. (2002) Cyclooxygenase-2 expression in human thyroid carcinoma and Hashimoto's thyroiditis. Laryngoscope 112:238-42
Zanesi, N; Fidanza, V; Fong, L Y et al. (2001) The tumor spectrum in FHIT-deficient mice. Proc Natl Acad Sci U S A 98:10250-5
Podolski, J; Byrski, T; Zajaczek, S et al. (2001) Characterization of a familial RCC-associated t(2;3)(q33;q21) chromosome translocation. J Hum Genet 46:685-93
Druck, T; Podolski, J; Byrski, T et al. (2001) The DIRC1 gene at chromosome 2q33 spans a familial RCC-associated t(2;3)(q33;q21) chromosome translocation. J Hum Genet 46:583-9
Powell Jr, D J; Russell, J P; Li, G et al. (2001) Altered gene expression in immunogenic poorly differentiated thyroid carcinomas from RET/PTC3p53-/- mice. Oncogene 20:3235-46
Daheron, L; Zenz, T; Siracusa, L D et al. (2001) Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity. Nucleic Acids Res 29:1308-16
Falvella, F S; Menegola, E; Giavini, E et al. (2000) Expression of Fhit protein during mouse development. Anat Rec 260:208-11
Russell, J P; Powell, D J; Cunnane, M et al. (2000) The TRK-T1 fusion protein induces neoplastic transformation of thyroid epithelium. Oncogene 19:5729-35

Showing the most recent 10 out of 209 publications