The role of Core B is to provide the following services: (1) support for treatment planning, (2) quality assurance and delivery of treatments for patients enrolled in the clinical trials of Projects 1 and 2, (3) Monte Carlo computations and management of high-speed parallel processing system for all four projects, and (4) measurements in phantom for experimental verification and validation of computed dose distributions for all four projects. This core will also play a significant role in the implementation of new methods resulting from research in Projects 1 through 4. Examples include image-guided setup, respiratory-gating, new plan evaluation techniques, in vivo dosimetry, reduced margins, adaptive replanning and intensity modulated proton therapy. For Project 1 (non-small cell lung cancers) and Project 2 (other challenging sites) treatment site-specific support will be provided for 1) immobilization, imaging (including repeat imaging and 4D imaging) and treatment set up;(2) planning of PSPT and IMPT, incorporation of results of research into treatment plan design and evaluation strategies and maintenance of proton treatment planning infrastructure;(3) quality assurance of new planning and treatment techniques prior to their clinical implementation;(4) patient specific dosimetric quality assurance;(5) image-guided setup and respiratory-gating;and (6) in-vivo dosimetry. The high-speed parallel CPU cluster system will be used for Monte Carlo calculations, optimization and image processing for all four projects. Because of the differences in equipment, systems and processes between MGH and MDACC, Core B has been divided into two parts. Core B1 will support MGH activities whereas Core B2 will support the MDACC activities

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA021239-32
Application #
8336789
Study Section
Special Emphasis Panel (ZCA1)
Project Start
2011-09-21
Project End
2014-07-31
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
32
Fiscal Year
2011
Total Cost
$31,384
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Pulsifer, Margaret B; Duncanson, Haley; Grieco, Julie et al. (2018) Cognitive and Adaptive Outcomes After Proton Radiation for Pediatric Patients With Brain Tumors. Int J Radiat Oncol Biol Phys 102:391-398
Liao, Zhongxing; Lee, J Jack; Komaki, Ritsuko et al. (2018) Bayesian Adaptive Randomization Trial of Passive Scattering Proton Therapy and Intensity-Modulated Photon Radiotherapy for Locally Advanced Non-Small-Cell Lung Cancer. J Clin Oncol 36:1813-1822
Jeter, Melenda D; Gomez, Daniel; Nguyen, Quynh-Nhu et al. (2018) Simultaneous Integrated Boost for Radiation Dose Escalation to the Gross Tumor Volume With Intensity Modulated (Photon) Radiation Therapy or Intensity Modulated Proton Therapy and Concurrent Chemotherapy for Stage II to III Non-Small Cell Lung Cancer: A P Int J Radiat Oncol Biol Phys 100:730-737
Frank, Steven J; Blanchard, Pierre; Lee, J Jack et al. (2018) Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation. Semin Radiat Oncol 28:108-113
Lin, Yu-Fen; Chen, Benjamin P; Li, Wende et al. (2018) The Relative Biological Effect of Spread-Out Bragg Peak Protons in Sensitive and Resistant Tumor Cells. Int J Part Ther 4:33-39
Ning, Matthew S; Tang, Linglong; Gomez, Daniel R et al. (2017) Incidence and Predictors of Pericardial Effusion After Chemoradiation Therapy for Locally Advanced Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 99:70-79
Chang, Joe Y; Zhang, Wencheng; Komaki, Ritsuko et al. (2017) Long-term outcome of phase I/II prospective study of dose-escalated proton therapy for early-stage non-small cell lung cancer. Radiother Oncol 122:274-280
Sanford, Nina N; Yeap, Beow Y; Larvie, Mykol et al. (2017) Prospective, Randomized Study of Radiation Dose Escalation With Combined Proton-Photon Therapy for Benign Meningiomas. Int J Radiat Oncol Biol Phys 99:787-796
Taylor, Paige A; Kry, Stephen F; Followill, David S (2017) Pencil Beam Algorithms Are Unsuitable for Proton Dose Calculations in Lung. Int J Radiat Oncol Biol Phys 99:750-756
Yock, Torunn I; Yeap, Beow Y; Ebb, David H et al. (2016) Long-term toxic effects of proton radiotherapy for paediatric medulloblastoma: a phase 2 single-arm study. Lancet Oncol 17:287-98

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