Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
3P01CA022507-13S1
Application #
3093003
Study Section
Special Emphasis Panel (SRC (L2))
Project Start
1978-01-01
Project End
1991-12-31
Budget Start
1990-05-01
Budget End
1991-12-31
Support Year
13
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
King, P D; Sadra, A; Teng, J M et al. (1997) Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases, EMT and LCK. J Immunol 158:580-90
Selvakumar, A; Steffens, U; Dupont, B (1996) NK cell receptor gene of the KIR family with two IG domains but highest homology to KIR receptors with three IG domains. Tissue Antigens 48:285-94
August, A; Dupont, B (1996) Association between mitogen-activated protein kinase and the zeta chain of the T cell receptor (TcR) with the SH2,3 domain of p56lck. Differential regulation by TcR cross-linking. J Biol Chem 271:10054-9
Gibson, S; August, A; Kawakami, Y et al. (1996) The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT. J Immunol 156:2716-22
Teng, J M; King, P D; Sadra, A et al. (1996) Phosphorylation of each of the distal three tyrosines of the CD28 cytoplasmic tail is required for CD28-induced T cell IL-2 secretion. Tissue Antigens 48:255-64
Teng, J M; Liu, X R; Mills, G B et al. (1996) CD28-mediated cytotoxicity by the human leukemic NK cell line YT involves tyrosine phosphorylation, activation of phosphatidylinositol 3-kinase, and protein kinase C. J Immunol 156:3222-32
King, P D; Sadra, A; Han, A et al. (1996) CD2 signaling in T cells involves tyrosine phosphorylation and activation of the Tec family kinase, EMT/ITK/TSK. Int Immunol 8:1707-14
Gibson, S; August, A; Branch, D et al. (1996) Functional LCK Is required for optimal CD28-mediated activation of the TEC family tyrosine kinase EMT/ITK. J Biol Chem 271:7079-83
Bannish, G; Hume, C; Lee, J S (1996) Coordinate regulation of HLA class II genes: a novel DNA binding complex. Mol Immunol 33:407-15
August, A; Dupont, B (1995) Activation of extracellular signal-regulated protein kinase (ERK/MAP kinase) following CD28 cross-linking: activation in cells lacking p56lck. Tissue Antigens 46:155-62

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