Abstract

For the past thirteen years, the Transplantation Biology Unit at UCLA has been involved in a continuing program of bone marrow transplantation and alternative therapies in the treatment of patients with aplastic anemia, leukemia, cancer, and immunodeficiency diseases. Many of these patients have become long-term survivors but considerable problems remain to be addressed including prevention of graft rejection, graft-vs-host disease (GVHD), delay of immune reconstitution and interstitial pneumonia. This proposal outlines our ongoing studies in three major program areas: (1) clinical trials; (2) the immunobiology of bone marrow transplantation and (3) application of hematopoietic growth Factors for transplant recipients and for treatment of hematologic diseases. These studies include preclinical studies in dogs and controlled clinical trials in patients with hematologic malignancies and aplastic anemia. The objective of the proposed project is to determine the role of bone marrow transplantation in human disease and improve the results of its application by an in- depth analysis of basic problems of transplantation biology in animals and by appropriate clinical trials.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA023175-08
Application #
3093045
Study Section
Clinical Cancer Program Project Review Committee (CCP)
Project Start
1983-07-15
Project End
1991-05-31
Budget Start
1987-07-01
Budget End
1988-05-31
Support Year
8
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Grovas, A; Feig, S A; O'Rourke, S et al. (1994) Unrelated donor bone marrow transplants in children. Cell Transplant 3:413-20
Nimer, S D; Giorgi, J; Gajewski, J L et al. (1994) Selective depletion of CD8+ cells for prevention of graft-versus-host disease after bone marrow transplantation. A randomized controlled trial. Transplantation 57:82-7
Todd, K; Wiley, F; Landaw, E et al. (1994) Survival outcome among 54 intubated pediatric bone marrow transplant patients. Crit Care Med 22:171-6
Aurer, I; Labar, B; Nemet, D et al. (1994) High incidence of conservative RAS mutations in acute myeloid leukemia. Acta Haematol 92:123-5
Winston, D J; Ho, W G; Bartoni, K et al. (1993) Intravenous immunoglobulin and CMV-seronegative blood products for prevention of CMV infection and disease in bone marrow transplant recipients. Bone Marrow Transplant 12:283-8
Schiller, G; Lee, M; Territo, M et al. (1993) Phase II study of etoposide, ifosfamide, and mitoxantrone for the treatment of resistant adult acute lymphoblastic leukemia. Am J Hematol 43:195-9
Winston, D J; Ho, W G; Bartoni, K et al. (1993) Ganciclovir prophylaxis of cytomegalovirus infection and disease in allogeneic bone marrow transplant recipients. Results of a placebo-controlled, double-blind trial. Ann Intern Med 118:179-84
Winston, D J; Chandrasekar, P H; Lazarus, H M et al. (1993) Fluconazole prophylaxis of fungal infections in patients with acute leukemia. Results of a randomized placebo-controlled, double-blind, multicenter trial. Ann Intern Med 118:495-503
Schiller, G J; Nimer, S D; Territo, M C et al. (1992) Bone marrow transplantation versus high-dose cytarabine-based consolidation chemotherapy for acute myelogenous leukemia in first remission. J Clin Oncol 10:41-6
Marin, T; Butturini, A; Kantarjian, H et al. (1992) Survival of children with chronic myeloid leukemia. Am J Pediatr Hematol Oncol 14:229-32

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