Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA025842-06
Application #
3962193
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1986
Total Cost
Indirect Cost
Name
St. Vincent Catholic Medical Center Nursing
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
11432
Martin, D S; Spriggs, D; Koutcher, J A (2001) A concomitant ATP-depleting strategy markedly enhances anticancer agent activity. Apoptosis 6:125-31
Koutcher, J A; Alfieri, A A; Tsai, J C et al. (1997) Evaluation of chemotherapy and radiation enhancement and 31P NMR spectral changes induced by biochemical modulation. Cancer Invest 15:111-20
Koutcher, J A; Alfieri, A A; Thaler, H et al. (1997) Radiation enhancement by biochemical modulation and 5-fluorouracil. Int J Radiat Oncol Biol Phys 39:1145-52
Martin, D S; Stolfi, R L; Colofiore, J R (1997) Perspective: the chemotherapeutic relevance of apoptosis and a proposed biochemical cascade for chemotherapeutically induced apoptosis. Cancer Invest 15:372-81
Street, J C; Alfieri, A A; Koutcher, J A (1997) Quantitation of metabolic and radiobiological effects of 6-aminonicotinamide in RIF-1 tumor cells in vitro. Cancer Res 57:3956-62
Kelsen, D P; Martin, D; O'Neil, J et al. (1997) Phase I trial of PN401, an oral prodrug of uridine, to prevent toxicity from fluorouracil in patients with advanced cancer. J Clin Oncol 15:1511-7
Street, J C; Koutcher, J A (1997) Effect of radiotherapy and chemotherapy on composition of tumor membrane phospholipids. Lipids 32:45-9
Nord, L D; Stolfi, R L; Alfieri, A A et al. (1997) Apoptosis induced in advanced CD8F1-murine mammary tumors by the combination of PALA, MMPR and 6AN precedes tumor regression and is preceded by ATP depletion. Cancer Chemother Pharmacol 40:376-84
Martin, D S; Schwartz, G K (1997) Chemotherapeutically induced DNA damage, ATP depletion, and the apoptotic biochemical cascade. Oncol Res 9:1-5
Stolfi, R L; Colofiore, J R; Nord, L D et al. (1996) Enhanced antitumor activity of an adriamycin + 5-fluorouracil combination when preceded by biochemical modulation. Anticancer Drugs 7:100-4

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