Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA027489-17
Application #
2087593
Study Section
Special Emphasis Panel (SRC (CC))
Project Start
1980-05-01
Project End
2000-02-29
Budget Start
1996-02-29
Budget End
1997-02-28
Support Year
17
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Zhu, Xueyong; Tanaka, Fujie; Lerner, Richard A et al. (2009) Direct observation of an enamine intermediate in amine catalysis. J Am Chem Soc 131:18206-7
Kamikubo, Yuichi; Kroon, Gerard; Curriden, Scott A et al. (2006) The reduced, denatured somatomedin B domain of vitronectin refolds into a stable, biologically active molecule. Biochemistry 45:3297-306
Zhu, Xueyong; Wentworth Jr, Paul; Kyle, Robert A et al. (2006) Cofactor-containing antibodies: crystal structure of the original yellow antibody. Proc Natl Acad Sci U S A 103:3581-5
Steiner, Derek D; Mase, Nobuyuki; Barbas 3rd, Carlos F (2005) Direct asymmetric alpha-fluorination of aldehydes. Angew Chem Int Ed Engl 44:3706-10
Suri, Jeff T; Ramachary, Dhevalapally B; Barbas 3rd, Carlos F (2005) Mimicking dihydroxy acetone phosphate-utilizing aldolases through organocatalysis: a facile route to carbohydrates and aminosugars. Org Lett 7:1383-5
Chowdari, Naidu S; Barbas 3rd, Carlos F (2005) Total synthesis of LFA-1 antagonist BIRT-377 via organocatalytic asymmetric construction of a quaternary stereocenter. Org Lett 7:867-70
Ramachary, Dhevalapally B; Barbas 3rd, Carlos F (2005) Direct amino acid-catalyzed asymmetric desymmetrization of meso-compounds: tandem aminoxylation/O-N bond heterolysis reactions. Org Lett 7:1577-80
Suri, Jeff T; Steiner, Derek D; Barbas 3rd, Carlos F (2005) Organocatalytic enantioselective synthesis of metabotropic glutamate receptor ligands. Org Lett 7:3885-8
Tanaka, Fujie; Fuller, Roberta; Barbas 3rd, Carlos F (2005) Development of small designer aldolase enzymes: catalytic activity, folding, and substrate specificity. Biochemistry 44:7583-92
Heine, Andreas; Luz, John G; Wong, Chi-Huey et al. (2004) Analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99A resolution. J Mol Biol 343:1019-34

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