The Behavioral Sciences Core has two components: shared resource, or service, and behavioral science research. The first centralizes resources to support developed interventions: (1) Chemoprevention of Skin Cancer by Retinoids; (2) Actinic Keratosis Phase I and II trials; (2) Beta-carotene clinical pharmacology study; (3) Beta-carotene and Vitamin E clinical pharmacology study; and (4) Phase II oral leukoplakia trials with behavioral components.
The aims of the shared resource component are: (1) adherence/compliance enhancement for all trials named above; (2) Behavioral science support for applicable developmental studies; and (3) Consultation with other Cores and projects. Hypotheses for the research component are: (1) the adherence enhancement strategy per the Health Behavior in Cancer Prevention Model predicts short and long term adherence in cancer prevention and control trial samples; (2) Health Behavior Profiles differ for good, marginal and poor adherers; (3) The adherence enhancement strategy is associated with good adherence. The correlational descriptive design for H3 is a prospective case control study of a subsample of poor and marginal compliers with matched good complier controls in trials with n>-100. The case control study sample estimate is 84 based on current study levels of marginal/poor compliers. DFMO/Retin-A (n=120) trial subjects are 40-80 year old men. Subjects in the Phase II oral leukoplakia (n=143) trial are also approximately 40-80 years old men and women. Other trials have less than 100 subjects. Analyses for H1 include OLS and LOGIT, graphic analysis for H2 and H3, and conditional LOGIT for H3. Study outcomes include description and explanation of factors in adherence failure, and a test of the effectiveness of the general and individualized compliance interventions.
| Blohm-Mangone, Karen; Burkett, Nichole B; Tahsin, Shekha et al. (2018) Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice. Cancer Prev Res (Phila) 11:265-278 |
| Knights-Mitchell, Shellie S; Romanowski, Marek (2018) Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes. Nanotheranostics 2:295-305 |
| Roh, Eunmiri; Lee, Mee-Hyun; Zykova, Tatyana A et al. (2018) Targeting PRPK and TOPK for skin cancer prevention and therapy. Oncogene 37:5633-5647 |
| Yamamoto, Hiroyuki; Ryu, Joohyun; Min, Eli et al. (2017) TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis. J Invest Dermatol 137:1322-1332 |
| Zykova, Tatyana A; Zhu, Feng; Wang, Lei et al. (2017) The T-LAK Cell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis. EBioMedicine 18:73-82 |
| Einspahr, Janine G; Curiel-Lewandrowski, Clara; Calvert, Valerie S et al. (2017) Protein activation mapping of human sun-protected epidermis after an acute dose of erythemic solar simulated light. NPJ Precis Oncol 1: |
| Gao, Ge; Zhang, Tianshun; Wang, Qiushi et al. (2017) ADA-07 Suppresses Solar Ultraviolet-Induced Skin Carcinogenesis by Directly Inhibiting TOPK. Mol Cancer Ther 16:1843-1854 |
| Chen, Yin; Vasquez, Monica M; Zhu, Lingxiang et al. (2017) Effects of Retinoids on Augmentation of Club Cell Secretory Protein. Am J Respir Crit Care Med 196:928-931 |
| Glazer, Evan S; Bartels, Peter H; Lian, Fangru et al. (2016) Quantitative histopathology identifies patients with thin melanomas who are at risk for metastases. Melanoma Res 26:261-6 |
| Franklin, Stephen J; Younis, Usir S; Myrdal, Paul B (2016) Estimating the Aqueous Solubility of Pharmaceutical Hydrates. J Pharm Sci 105:1914-1919 |
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