The Analytical Chemistry Core will provide support in the analytical chemistry area for all projects in the proposed Program Project. The primary responsibility of this Core will be to analyze the sample submitted by the project investigators accurately and timely so that the investigators can evaluate the data with confidence before planning the next phase of their investigations. The compounds to be analyzed are retinol, retinyl-palmitate, all-trans-retinoic acid, 13-cis-retinoic acid, vitamin E, beta-carotene, lycopene, selenium, antipyrine and difluormethylornithine in human and animal plasma, skin, buccal mucosa cells, liver, and subcutaneous fat. Our assay procedures for these compounds are well established and have been published in peer-reviewed journals. In order to generate accurate and consistent data, the Core will continue to follow the extensive quality control/quality assurance program we have developed and carried out while maintaining the existing strong-tie with the National Bureau of Standards. The Core will also provide consultations to the investigators regarding the interpretation of analytical data and/or any matters related to analytical chemistry. In addition, this Core will keep abreast of current developments in the field of analytical chemistry in order to meet any special analytical problems the Core may face in the future. The laboratory of this Core is well equipped with up-to-date analytical instrument and the Principal Investigator and the staff members of the Core have extensive knowledge and experience in carrying out all the tasks mentioned above.
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| Knights-Mitchell, Shellie S; Romanowski, Marek (2018) Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes. Nanotheranostics 2:295-305 |
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| Chen, Yin; Vasquez, Monica M; Zhu, Lingxiang et al. (2017) Effects of Retinoids on Augmentation of Club Cell Secretory Protein. Am J Respir Crit Care Med 196:928-931 |
| Yamamoto, Hiroyuki; Ryu, Joohyun; Min, Eli et al. (2017) TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis. J Invest Dermatol 137:1322-1332 |
| Zykova, Tatyana A; Zhu, Feng; Wang, Lei et al. (2017) The T-LAK Cell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis. EBioMedicine 18:73-82 |
| Einspahr, Janine G; Curiel-Lewandrowski, Clara; Calvert, Valerie S et al. (2017) Protein activation mapping of human sun-protected epidermis after an acute dose of erythemic solar simulated light. NPJ Precis Oncol 1: |
| Gao, Ge; Zhang, Tianshun; Wang, Qiushi et al. (2017) ADA-07 Suppresses Solar Ultraviolet-Induced Skin Carcinogenesis by Directly Inhibiting TOPK. Mol Cancer Ther 16:1843-1854 |
| Glazer, Evan S; Bartels, Peter H; Lian, Fangru et al. (2016) Quantitative histopathology identifies patients with thin melanomas who are at risk for metastases. Melanoma Res 26:261-6 |
| Franklin, Stephen J; Younis, Usir S; Myrdal, Paul B (2016) Estimating the Aqueous Solubility of Pharmaceutical Hydrates. J Pharm Sci 105:1914-1919 |
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