The Analytical Chemistry Core, under the supervision of Dr. Yei-Mei Peng, will continue to provide support and service In the analytical chemistry area to all the proposed projects. The primary responsibility of this Core continues to be the analysis of the submitted biological samples in an accurate and timely manner for the investigators. The specific assays provided by this Core will Include: retinol, retinyl palmitate, beta- carotene, alpha-tocopherol, alpha-tocopheryl acetate, alpha-tocopheryl succinate, difluoromethylornithine (DfMO), nicotinamide, tannic acid, polyamines, prostaglandin E2D BrdU and PCNA labeling index, and mutant Ha-ras gene and p53 gene copy numbers. In addition, the Core will develop methods for the analysis of new compounds and also conduct research on the chemical properties and stability of the compounds of interest to ensure the proper handling and storage of biological samples prior to analysis. To assure the accuracy and consistency of our analytical data, the Core will continue to follow the existing quality control/quality assurance program we developed as well as the program of the National Institute of Standards and Technology. The fatty Acid Analysis Core, under the supervision of Dr. Donald McNamara, will provide service and support In the area of fatty acid analysis for project III. The Cytofluorography Core, under the supervision of Dr. Raymond Taetle, will perform assays to monitor lymphocyte subpopulations in peripheral blood for projects IIC and IVA. This core will also advice project III for the detection of cell surface markers on melanocytes and project IVB for the detection of T- cells that home to the skin.
| Blohm-Mangone, Karen; Burkett, Nichole B; Tahsin, Shekha et al. (2018) Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice. Cancer Prev Res (Phila) 11:265-278 |
| Knights-Mitchell, Shellie S; Romanowski, Marek (2018) Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes. Nanotheranostics 2:295-305 |
| Roh, Eunmiri; Lee, Mee-Hyun; Zykova, Tatyana A et al. (2018) Targeting PRPK and TOPK for skin cancer prevention and therapy. Oncogene 37:5633-5647 |
| Yamamoto, Hiroyuki; Ryu, Joohyun; Min, Eli et al. (2017) TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis. J Invest Dermatol 137:1322-1332 |
| Zykova, Tatyana A; Zhu, Feng; Wang, Lei et al. (2017) The T-LAK Cell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis. EBioMedicine 18:73-82 |
| Einspahr, Janine G; Curiel-Lewandrowski, Clara; Calvert, Valerie S et al. (2017) Protein activation mapping of human sun-protected epidermis after an acute dose of erythemic solar simulated light. NPJ Precis Oncol 1: |
| Gao, Ge; Zhang, Tianshun; Wang, Qiushi et al. (2017) ADA-07 Suppresses Solar Ultraviolet-Induced Skin Carcinogenesis by Directly Inhibiting TOPK. Mol Cancer Ther 16:1843-1854 |
| Chen, Yin; Vasquez, Monica M; Zhu, Lingxiang et al. (2017) Effects of Retinoids on Augmentation of Club Cell Secretory Protein. Am J Respir Crit Care Med 196:928-931 |
| Glazer, Evan S; Bartels, Peter H; Lian, Fangru et al. (2016) Quantitative histopathology identifies patients with thin melanomas who are at risk for metastases. Melanoma Res 26:261-6 |
| Franklin, Stephen J; Younis, Usir S; Myrdal, Paul B (2016) Estimating the Aqueous Solubility of Pharmaceutical Hydrates. J Pharm Sci 105:1914-1919 |
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