The Surrogate Endpoint Biomarker (SEB) Core will serve as a resource and service for carrying out laboratory analyses related to this project. The core has developed, validated, and standardized sample collection, sample preparation, and sample analysis procedures for blood and skin biopsies described in this core. Additionally, we will continue to optimize methods for measuring SEBs to be used in the projects. The SEBs to be analyzed by the SEB Core will include histopathology, morphometry, agent levels (blood and skin biopsy), cell proliferation measured by immunohistochemical detection of proliferating cell nuclear antigen (PCNA), expression of p53 protein by immunohistochemistry, measurement of apoptotic rate (morphology and in situ TUNEL), and the development of assays for AP1 activity and UV dimer formation (immunohistochemistry). The SEB Core will oversee and coordinate the collection and processing of all samples related to this Program Project at the clinic site, including distribution to the Molecular Genetics Core. The SEB core will be responsible for training of personnel involved in the collection and processing of study samples. The core will perform SEB assays and will work closely with the Biometry Core to provide raw data for analysis and interpretation. Quality assurance and quality control procedures will continue to be developed by the SEB Core and will be supervised by the Biometry Core for sample acquisition, processing, and analysis procedures included in each of the projects.
| Blohm-Mangone, Karen; Burkett, Nichole B; Tahsin, Shekha et al. (2018) Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice. Cancer Prev Res (Phila) 11:265-278 |
| Knights-Mitchell, Shellie S; Romanowski, Marek (2018) Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes. Nanotheranostics 2:295-305 |
| Roh, Eunmiri; Lee, Mee-Hyun; Zykova, Tatyana A et al. (2018) Targeting PRPK and TOPK for skin cancer prevention and therapy. Oncogene 37:5633-5647 |
| Einspahr, Janine G; Curiel-Lewandrowski, Clara; Calvert, Valerie S et al. (2017) Protein activation mapping of human sun-protected epidermis after an acute dose of erythemic solar simulated light. NPJ Precis Oncol 1: |
| Gao, Ge; Zhang, Tianshun; Wang, Qiushi et al. (2017) ADA-07 Suppresses Solar Ultraviolet-Induced Skin Carcinogenesis by Directly Inhibiting TOPK. Mol Cancer Ther 16:1843-1854 |
| Chen, Yin; Vasquez, Monica M; Zhu, Lingxiang et al. (2017) Effects of Retinoids on Augmentation of Club Cell Secretory Protein. Am J Respir Crit Care Med 196:928-931 |
| Yamamoto, Hiroyuki; Ryu, Joohyun; Min, Eli et al. (2017) TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis. J Invest Dermatol 137:1322-1332 |
| Zykova, Tatyana A; Zhu, Feng; Wang, Lei et al. (2017) The T-LAK Cell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis. EBioMedicine 18:73-82 |
| Glazer, Evan S; Bartels, Peter H; Lian, Fangru et al. (2016) Quantitative histopathology identifies patients with thin melanomas who are at risk for metastases. Melanoma Res 26:261-6 |
| Franklin, Stephen J; Younis, Usir S; Myrdal, Paul B (2016) Estimating the Aqueous Solubility of Pharmaceutical Hydrates. J Pharm Sci 105:1914-1919 |
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