The goal of the Chemoprevention of Skin Cancer (CSC) Biometry Core is to collaborate with all investigators in development and application of statistical methocis for design, conduct and analysis of all projects, including data management and computing support, This goal is achieved through the following specific aims: 1, To provide statistical and epidemiological collaboration in the design and execution of all projects. 2, To develop procedures for data collection, and build and maintain computer databases for information storage and retrieval. 3, To provide interim reports on individual study progress. 4, To provide statistical analysis and participate in writing manuscripts for publication. 5, To provide an administrative link between Core D and Project 3 in terms of managing and accounting for study agents. Biometry support is required in all phases of program studies, At the design phase, the core staff addresses statistical design, analysis methocis, power and sample size issues, and works with other investigators to establish data management and quality control procedures. They then participate in the management, oversight and interim reporting of ongoing studies. Upon study completion, core personnel perform statistical analyses in collaboration with other investigators and participate in preparation of manuscripts for publication. As a unique expertise, the core provides support in the design and analysis of studies involving karyometric endpoints. The Biometry Core continues to be used by all investigators in both clinical and laboratory settings. This highly interactive and clinically translational research program project focuses on the successful preclinical testing of targeted chemoprevention agents in innovative mouse models (Projects 1 and 2) followed by the design and implementation of clinical trials in at risk human populations (Project 3). Detailed descriptions ofthe decision-tree selection process as well as the interactions between Projects and Cores are found on the Resources Format Page.
The Biometry Core interacts with all CSCPP investigators to insure that their scientific questions are addressed through stringent research design and appropriate statistical methods, resulting in valid and reliable results suitable for dissemination and publication.
|Blohm-Mangone, Karen; Burkett, Nichole B; Tahsin, Shekha et al. (2018) Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice. Cancer Prev Res (Phila) 11:265-278|
|Knights-Mitchell, Shellie S; Romanowski, Marek (2018) Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes. Nanotheranostics 2:295-305|
|Roh, Eunmiri; Lee, Mee-Hyun; Zykova, Tatyana A et al. (2018) Targeting PRPK and TOPK for skin cancer prevention and therapy. Oncogene 37:5633-5647|
|Chen, Yin; Vasquez, Monica M; Zhu, Lingxiang et al. (2017) Effects of Retinoids on Augmentation of Club Cell Secretory Protein. Am J Respir Crit Care Med 196:928-931|
|Yamamoto, Hiroyuki; Ryu, Joohyun; Min, Eli et al. (2017) TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis. J Invest Dermatol 137:1322-1332|
|Zykova, Tatyana A; Zhu, Feng; Wang, Lei et al. (2017) The T-LAK Cell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis. EBioMedicine 18:73-82|
|Einspahr, Janine G; Curiel-Lewandrowski, Clara; Calvert, Valerie S et al. (2017) Protein activation mapping of human sun-protected epidermis after an acute dose of erythemic solar simulated light. NPJ Precis Oncol 1:|
|Gao, Ge; Zhang, Tianshun; Wang, Qiushi et al. (2017) ADA-07 Suppresses Solar Ultraviolet-Induced Skin Carcinogenesis by Directly Inhibiting TOPK. Mol Cancer Ther 16:1843-1854|
|Glazer, Evan S; Bartels, Peter H; Lian, Fangru et al. (2016) Quantitative histopathology identifies patients with thin melanomas who are at risk for metastases. Melanoma Res 26:261-6|
|Franklin, Stephen J; Younis, Usir S; Myrdal, Paul B (2016) Estimating the Aqueous Solubility of Pharmaceutical Hydrates. J Pharm Sci 105:1914-1919|
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