N-Nitroso Compounds and Gastric Cancer

Tannenbaum, Steven R.

Abstract

Our previous investigations have centered on a population-based study in Colombia to determine whether nitrate, N-nitrosoproline (NPro) and/or 3- methyladenine were related to the histopathological status of the gastric mucosa. We have discovered that only individuals diagnosed as having intestinal metaplasia or dysplasia (IM) of the stomach show a high degree of correlation between urinary nitrate and urinary N-nitrosoproline. Individuals with normal or chronic gastritis mucosa showed no correlation. A possible explanation for this observation is the loss of reduced ascorbic acid from gastric juice of IM individuals. We will further test the hypothesis that IM leads to increased synthesis of N-nitroso compounds and that increased dietary ascorbic acid inhibits nitrosation. In addition to direct measures of N-nitroso compounds, 15NO3 will be used to establish gastric losses and incorporation of 15N into NPro in individuals with IM compared to normal gastric mucosa. This proposal is a further test of the hypothesis that endogenously formed N-nitroso compounds are risk factors for gastric cancer.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Program Projects (P01)
• Project #: 5P01CA028842-12
• Application #: 3749785
• Support Year: 12
• Fiscal Year: 1994

Institution

• Name: Louisiana State University Hsc New Orleans
• DUNS #: 782627814
• City: New Orleans
• State: LA
• Country: United States
• Zip Code: 70112

Publications

Singh, Kshipra; Coburn, Lori A; Asim, Mohammad et al. (2018) Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Cancer Res 78:4303-4315

Ge, Zhongming; Sheh, Alexander; Feng, Yan et al. (2018) Helicobacter pylori-infected C57BL/6 mice with different gastrointestinal microbiota have contrasting gastric pathology, microbial and host immune responses. Sci Rep 8:8014

Gobert, Alain P; Al-Greene, Nicole T; Singh, Kshipra et al. (2018) Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection. Front Immunol 9:1242

Estevez-Ordonez, Dagoberto; Montalvan-Sanchez, Eleazar E; Wong, Rochelle E et al. (2018) Health Barriers and Patterns of Gastric Cancer Care in Rural Central American Resource-Limited Settings. JAMA Oncol 4:1131-1133

Scoville, Elizabeth A; Allaman, Margaret M; Brown, Caroline T et al. (2018) Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn's Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling. Metabolomics 14:

Sierra, Johanna C; Asim, Mohammad; Verriere, Thomas G et al. (2018) Epidermal growth factor receptor inhibition downregulates Helicobacter pylori-induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis. Gut 67:1247-1260

Blosse, Alice; Lehours, Philippe; Wilson, Keith T et al. (2018) Helicobacter: Inflammation, immunology, and vaccines. Helicobacter 23 Suppl 1:e12517

Piñeros, Marion; Frech, Silvina; Frazier, Lindsay et al. (2018) Advancing Reliable Data for Cancer Control in the Central America Four Region. J Glob Oncol :1-11

González-Pons, María; Soto-Salgado, Marievelisse; Sevilla, Javier et al. (2018) Seroprevalence of Helicobacter pylori in Hispanics living in Puerto Rico: A population-based study. Helicobacter 23:

Coburn, Lori A; Singh, Kshipra; Asim, Mohammad et al. (2018) Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis. Oncogene :