The objective of this Program Project is the multidisciplinary study of the etiology of gastric cancer, focused on premalignant lesions. The current cycle is based on findings of the previous funding cycles which have led to the postulation and refinement of an etiologic model. The first project is the continuation of a chemoprevention trial designed to determine the efficacy of antioxidant supplementation (ascorbic acid and/or beta carotene) and/or anti-Helicobacter pylori treatment in retarding the progression of the premalignant process. The second project provides an evaluation of the histological and molecular endpoints used in all the other components of the program. All of the proposed studies are closely interrelated and complementary. They explore the mechanisms of action of the factors involved in the gastric precancerous process and its possible inhibition. These studies have the potential to provide important new knowledge about gastric carcinogenesis and to contribute to the goal of primary prevention of this common cancer.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Study Section
Cancer Centers and Research Programs Review Committee (CCRP)
Program Officer
Patel, Appasaheb1 R
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Louisiana State University Hsc New Orleans
Schools of Dentistry
New Orleans
United States
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Blosse, Alice; Lehours, Philippe; Wilson, Keith T et al. (2018) Helicobacter: Inflammation, immunology, and vaccines. Helicobacter 23 Suppl 1:e12517
Piñeros, Marion; Frech, Silvina; Frazier, Lindsay et al. (2018) Advancing Reliable Data for Cancer Control in the Central America Four Region. J Glob Oncol :1-11
González-Pons, María; Soto-Salgado, Marievelisse; Sevilla, Javier et al. (2018) Seroprevalence of Helicobacter pylori in Hispanics living in Puerto Rico: A population-based study. Helicobacter 23:
Coburn, Lori A; Singh, Kshipra; Asim, Mohammad et al. (2018) Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis. Oncogene :
Noto, Jennifer M; Chopra, Abha; Loh, John T et al. (2018) Pan-genomic analyses identify key Helicobacter pylori pathogenic loci modified by carcinogenic host microenvironments. Gut 67:1793-1804
Hagen, Susan J; Ang, Lay-Hong; Zheng, Yi et al. (2018) Loss of Tight Junction Protein Claudin 18 Promotes Progressive Neoplasia Development in Mouse Stomach. Gastroenterology 155:1852-1867
Bravo, Luis Eduardo; García, Luz Stella; Collazos, Paola et al. (2018) Reliable information for cancer control in Cali, Colombia. Colomb Med (Cali) 49:23-34
Mera, Robertino M; Bravo, Luis E; Camargo, M Constanza et al. (2018) Dynamics of Helicobacter pylori infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial. Gut 67:1239-1246
García, Luz Stella; Bravo, Luis Eduardo; Collazos, Paola et al. (2018) Cali cancer registry methods. Colomb Med (Cali) 49:109-120
Singh, Kshipra; Coburn, Lori A; Asim, Mohammad et al. (2018) Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Cancer Res 78:4303-4315

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