Dr. Luis Eduardo Bravo is the Principal Investigator and supervises all activities in Colombia. He is based in Cali and travels often to Pasto. His administrative assistant in Cali is Mr. Tito Collazos who has been the administrator for all the life of the Program Project. Mr. Collazos coordinates the clinical work conducted at Hospital Departamental of Pasto and Hospital San Andres in Tumaco. He also collaborates with Nurse Maria Clara Yepez, in-charge of the children's cohorts at Universidad de Narino. Dr. Bravo's data manager assistant is Mrs. Stella Garcia, who has been in charge of those activities for approximately 10 years and has become extraordinarily skilled and efficient. The data generated in Pasto are entered and edited by Mrs. Alicia Rosero, who also has been conducting these activities very efficiently for years. Mrs. Rosero transmits the data via internet to Nashville and Raleigh, NC for Dr. Robertino Mera. The field team in Narino is under the direction of Dr. Guillermo Zarama, who is also the gastroenterologist and endoscopist in charge. He is based at Hospital Departamental. The field team is based at Universidad de Narino (Pasto) under the direction of Nurse Maria Clara Yepez. She has trained outstanding assistants (nurses-social workers). Mrs. Cristina Campo supervises the clinical nursing and data managing team in Narino. Dr. Juan Carios Bravo is assistant pathologist for gastric biopsies interpretation. The biopsies are fixed and embedded in paraffin in Colombia. A first section is stained and used for diagnostic uses communicated to the clinician. The paraffin blocks are then transported to Nashville for further processing, immunohistochemistry, and other special procedures.

Public Health Relevance

In Colombia there are unique subpopulations, not available in the United States, displaying marked contrasts in terms of risk of gastric cancer and infection with the bacterium Helicobacter pylori, a recognized cause of gastric cancer. The infrastructure to study such populations has been developed over the years and is very efficient.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA028842-28
Application #
8540098
Study Section
Special Emphasis Panel (ZCA1-GRB-P)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
28
Fiscal Year
2013
Total Cost
$152,111
Indirect Cost
$38,847
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Scoville, Elizabeth A; Allaman, Margaret M; Brown, Caroline T et al. (2018) Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn's Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling. Metabolomics 14:
Sierra, Johanna C; Asim, Mohammad; Verriere, Thomas G et al. (2018) Epidermal growth factor receptor inhibition downregulates Helicobacter pylori-induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis. Gut 67:1247-1260
Blosse, Alice; Lehours, Philippe; Wilson, Keith T et al. (2018) Helicobacter: Inflammation, immunology, and vaccines. Helicobacter 23 Suppl 1:e12517
Piñeros, Marion; Frech, Silvina; Frazier, Lindsay et al. (2018) Advancing Reliable Data for Cancer Control in the Central America Four Region. J Glob Oncol :1-11
González-Pons, María; Soto-Salgado, Marievelisse; Sevilla, Javier et al. (2018) Seroprevalence of Helicobacter pylori in Hispanics living in Puerto Rico: A population-based study. Helicobacter 23:
Coburn, Lori A; Singh, Kshipra; Asim, Mohammad et al. (2018) Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis. Oncogene :
Noto, Jennifer M; Chopra, Abha; Loh, John T et al. (2018) Pan-genomic analyses identify key Helicobacter pylori pathogenic loci modified by carcinogenic host microenvironments. Gut 67:1793-1804
Hagen, Susan J; Ang, Lay-Hong; Zheng, Yi et al. (2018) Loss of Tight Junction Protein Claudin 18 Promotes Progressive Neoplasia Development in Mouse Stomach. Gastroenterology 155:1852-1867
Bravo, Luis Eduardo; García, Luz Stella; Collazos, Paola et al. (2018) Reliable information for cancer control in Cali, Colombia. Colomb Med (Cali) 49:23-34
Mera, Robertino M; Bravo, Luis E; Camargo, M Constanza et al. (2018) Dynamics of Helicobacter pylori infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial. Gut 67:1239-1246

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