Abstract

The objectives of this application are to provide programmatic and core funding for the cancer chemotherapy program of the Department of Pharmacology. The research component consists of projects which encompass drug design and synthesis, studies on the biochemical, biophysical and pharmacological mode of action of drugs in experimental systems and extrapolation of research into models of human disease and drug toxicity. A core component of essential resources that include an analytical laboratory and instrumentation, a tissue culture facility, a tumor bank and transplantation laboratory, an electron microscope resource, a drug synthesis laboratory, and administration forms the second part of the application.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA028852-05
Application #
3093244
Study Section
Cancer Therapeutics Program Project Review Committee (CTR)
Project Start
1984-02-01
Project End
1987-01-31
Budget Start
1985-02-01
Budget End
1986-01-31
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code

  Publications

Lazo, J S; Schisselbauer, J C; Meandzija, B et al. (1989) Initial single-strand DNA damage and cellular pharmacokinetics of bleomycin A2. Biochem Pharmacol 38:2207-13
Narayanan, R; Jastreboff, M M; Chiu, C F et al. (1988) A method to detect transfected chloramphenicol acetyltransferase gene expression in intact animals. Exp Cell Res 174:297-301
Lin, T S; Guo, J Y; Schinazi, R F et al. (1988) Synthesis and antiviral activity of various 3'-azido analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1, HTLV-III/LAV). J Med Chem 31:336-40
Lin, T S; Zhang, X H; Wang, Z H et al. (1988) Synthesis and antiviral evaluation of carbocyclic analogues of 2'-azido- and 2'-amino-2'-deoxycytidine. J Med Chem 31:484-6
Hait, W N; Lazo, J S; Chen, D L et al. (1988) Antitumor and toxic effects of combination chemotherapy with bleomycin and a phenothiazine anticalmodulin agent. J Natl Cancer Inst 80:246-50
Gamba-Vitalo, C; Blair, O C; Tritton, T R et al. (1987) Cytotoxicity and differentiating actions of adriamycin in WEHI-3B D+ leukemia cells. Leukemia 1:188-97
Burke, T G; Pritsos, C A; Sartorelli, A C et al. (1987) The structural basis for anthracycline antibiotic stimulation of oxygen consumption by HL-60 cells and mitochondria. Cancer Biochem Biophys 9:245-55
Sebti, S M; Lazo, J S (1987) Separation of the protective enzyme bleomycin hydrolase from rabbit pulmonary aminopeptidases. Biochemistry 26:432-7
Lin, T S; Schinazi, R F; Chen, M S et al. (1987) Antiviral activity of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) against human immunodeficiency virus in vitro. Biochem Pharmacol 36:311-6
Darnowski, J W; Holdridge, C; Handschumacher, R E (1987) Concentrative uridine transport by murine splenocytes: kinetics, substrate specificity, and sodium dependency. Cancer Res 47:2614-9

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