Core 3 - Animal Research

Lele, Padmakar P.

Abstract

This core facility will provide technological, veterinary, tumor transplantation, histological and statistical support for the biological studies to be conducted in experimental animals (mice, rats, dogs, pigs) and dog patients as well as to Physics and Technology projects which will utilize hyperthermia in animals to refine and validate their respective techniques, before application to human patients. It will thus directly serve all the projects in this program. Two local hyperthermia systems, one mechanical and the other computer controlled, complete with temperature monitoring and recording equipment, will be allocated to this core. The computer controlled system will be upgraded to make it (reliable and) compatible with clinical system, so that any software (or hardware) developed on either system can be used with the other system. This core will serve all the projects conducted by personnel not familiar with hyperthermia and will also be used for preliminary training of personnel from collaborating institutions who plan to duplicate the Hyperthermia System for clinical evaluation in their own institution.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Program Projects (P01)
• Project #: 2P01CA031303-04A1
• Application #: 3820499
• Support Year: 4
• Fiscal Year: 1988

Institution

• Name: Massachusetts Institute of Technology
• City: Cambridge
• State: MA
• Country: United States
• Zip Code: 02139

Publications

Hurwitz, Mark D; Hansen, Jorgen L; Prokopios-Davos, Savina et al. (2011) Hyperthermia combined with radiation for the treatment of locally advanced prostate cancer: long-term results from Dana-Farber Cancer Institute study 94-153. Cancer 117:510-6

Wang, XiaoZhe; Khaleque, Md Abdul; Zhao, Mei Juan et al. (2006) Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. J Biol Chem 281:782-91

Tonkiss, J; Calderwood, S K (2005) Regulation of heat shock gene transcription in neuronal cells. Int J Hyperthermia 21:433-44

Khaleque, Md Abdul; Bharti, Ajit; Sawyer, Douglas et al. (2005) Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth. Oncogene 24:6564-73

Hurwitz, Mark D; Kaplan, Irving D; Hansen, Jorgen L et al. (2005) Hyperthermia combined with radiation in treatment of locally advanced prostate cancer is associated with a favourable toxicity profile. Int J Hyperthermia 21:649-56

Calderwood, Stuart K (2005) Regulatory interfaces between the stress protein response and other gene expression programs in the cell. Methods 35:139-48

Calderwood, Stuart K; Theriault, Jimmy R; Gong, Jianlin (2005) How is the immune response affected by hyperthermia and heat shock proteins? Int J Hyperthermia 21:713-6

Calderwood, S K (2005) Evolving connections between molecular chaperones and neuronal function. Int J Hyperthermia 21:375-8

Tang, Dan; Khaleque, Md Abdul; Jones, Ellen L et al. (2005) Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo. Cell Stress Chaperones 10:46-58

Calderwood, Stuart K; Theriault, Jimmy R; Gong, Jianlin (2005) Message in a bottle: role of the 70-kDa heat shock protein family in anti-tumor immunity. Eur J Immunol 35:2518-27