The research program proposed in this competing renewal application consists of three closely interrelated and interdependent projects directed toward rigorous evaluation, utilization and refinement of a unique technique for localized and controllable heating of deep, as well as of extensive, intractable superficial tumors, combined with a technique for high density measurement of tissue temperature, perfusion and PO2. It represents logical continuation of the promising areas of the work presently being conducted. From studies during 670 sessions in 123 patients, the Scanned Intensity-Modulated Focused Ultrasound (SIMFU) system is found to be routinely capable of heating 10 cm x 10 cm x 10 cm tumors up to a depth of 12 cm to therapeutic temperatures, without toxicity to surrounding tissues. Confirmation of these data in a hospital setting and studies of clinical efficacy of local tumor hyperthermia alone or with drugs or radiation is the focus of the project to be conducted at the Dana Farber Cancer Institute. The other two projects are respectively aimed at further development, refinement, evaluation and integration of the SIMFU, and the thermal dosimetry systems.

National Institute of Health (NIH)
National Cancer Institute (NCI)
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Clinical Cancer Program Project Review Committee (CCP)
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Massachusetts Institute of Technology
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United States
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Hurwitz, Mark D; Hansen, Jorgen L; Prokopios-Davos, Savina et al. (2011) Hyperthermia combined with radiation for the treatment of locally advanced prostate cancer: long-term results from Dana-Farber Cancer Institute study 94-153. Cancer 117:510-6
Wang, XiaoZhe; Khaleque, Md Abdul; Zhao, Mei Juan et al. (2006) Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. J Biol Chem 281:782-91
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Khaleque, Md Abdul; Bharti, Ajit; Sawyer, Douglas et al. (2005) Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth. Oncogene 24:6564-73
Hurwitz, Mark D; Kaplan, Irving D; Hansen, Jorgen L et al. (2005) Hyperthermia combined with radiation in treatment of locally advanced prostate cancer is associated with a favourable toxicity profile. Int J Hyperthermia 21:649-56
Calderwood, Stuart K (2005) Regulatory interfaces between the stress protein response and other gene expression programs in the cell. Methods 35:139-48
Calderwood, Stuart K; Theriault, Jimmy R; Gong, Jianlin (2005) How is the immune response affected by hyperthermia and heat shock proteins? Int J Hyperthermia 21:713-6
Calderwood, S K (2005) Evolving connections between molecular chaperones and neuronal function. Int J Hyperthermia 21:375-8

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