Abstract

The overall goal of our program project grant is to define important mechanisms of human oncogenesis and extend such information to the development of innovative strategies for the prevention and treatment of human cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA032737-12
Application #
2088382
Study Section
Special Emphasis Panel (SRC (M1))
Project Start
1982-04-01
Project End
1995-07-31
Budget Start
1994-02-26
Budget End
1995-07-31
Support Year
12
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

O'Brien, Neil A; McDonald, Karen; Tong, Luo et al. (2014) Targeting PI3K/mTOR overcomes resistance to HER2-targeted therapy independent of feedback activation of AKT. Clin Cancer Res 20:3507-20
Short, John D; Dere, Ruhee; Houston, Kevin D et al. (2010) AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Mol Carcinog 49:429-39
Klichko, Yaroslav; Liong, Monty; Choi, Eunshil et al. (2009) Mesostructured Silica for Optical Functionality, Nanomachines, and Drug Delivery. J Am Ceram Soc 92:s2-s10
Lu, Jie; Chan, Lai; Fiji, Hannah D G et al. (2009) In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I. Mol Cancer Ther 8:1218-26
Lu, Jie; Choi, Eunshil; Tamanoi, Fuyuhiko et al. (2008) Light-activated nanoimpeller-controlled drug release in cancer cells. Small 4:421-6
Liong, Monty; Lu, Jie; Kovochich, Michael et al. (2008) Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery. ACS Nano 2:889-96
Watanabe, Masaru; Fiji, Hannah D G; Guo, Lea et al. (2008) Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds. J Biol Chem 283:9571-9
Short, John D; Houston, Kevin D; Dere, Ruhee et al. (2008) AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27. Cancer Res 68:6496-506
Lu, Jie; Liong, Monty; Sherman, Sean et al. (2007) Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells. Nanobiotechnology 3:89-95
Lu, Jie; Liong, Monty; Zink, Jeffrey I et al. (2007) Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs. Small 3:1341-6

Showing the most recent 10 out of 213 publications