Abstract

Our proposed research is concerned with quantitative mapping of the biological distribution of administered radioactive tracers in man an experimental animals using imaging techniques. Specifically the research projects deal with: (1) continued efforts to ellucidate the relationship between chemical structure and the biological distribution of technetium compounds; (2) development of new methods for radiolabeling monoclonal antibodies with technetium-99m; (3) design of new radiolabeled lipophillic cations and ellucidation of their mechanism of accumulation in the heart; (4) further synthesis of ligands for study of the cholinergic system; and (5) continued investigations of the relationship between chemical structure and the biological distribution of compounds bound by opiate receptors. The program is multidisciplinary, involving physicians, physicists, chemists, engineers and computer experts; and multidepartmental, involving departments of both the Schools of Medicine and Hygiene and Public Health of the Johns Hopkins Medical Institutions, and the Graduate Chemistry Division of the Johns Hopkins University. The program provides a focus for investigators in a continuing program oriented toward obtaining new knowledge about the dynamic state of body constituents by the application of a variety of new radioactive tracer techniques that we will design, develop, and evaluate.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA032845-26
Application #
3093476
Study Section
Clinical Cancer Program Project Review Committee (CCP)
Project Start
1977-12-01
Project End
1992-02-28
Budget Start
1988-03-01
Budget End
1989-02-28
Support Year
26
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Public Health
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Madar, Igal; Bencherif, Badredin; Lever, John et al. (2007) Imaging delta- and mu-opioid receptors by PET in lung carcinoma patients. J Nucl Med 48:207-13
Lin, Kuo-Shyan; Luu, Andrew; Baidoo, Kwamena E et al. (2005) A new high affinity technetium-99m-bombesin analogue with low abdominal accumulation. Bioconjug Chem 16:43-50
Hardwick, Matthew J; Chen, Ming-Kai; Baidoo, Kwamena et al. (2005) In vivo imaging of peripheral benzodiazepine receptors in mouse lungs: a biomarker of inflammation. Mol Imaging 4:432-8
Chen, Ming-Kai; Baidoo, Kwamena; Verina, Tatyana et al. (2004) Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization. Brain 127:1379-92
Lin, Kuo-Shyan; Luu, Andrew; Baidoo, Kwamena E et al. (2004) A new high affinity technetium analogue of bombesin containing DTPA as a pharmacokinetic modifier. Bioconjug Chem 15:1416-23
Lever, J R; Ilgin, N; Musachio, J L et al. (1998) Autoradiographic and SPECT imaging of cerebral opioid receptors with an iodine-123 labeled analogue of diprenorphine. Synapse 29:172-82
Sanchez-Roa, P M; Wagner Jr, H N; Villemagne, V L et al. (1998) Effects of extracellular acetylcholine on muscarinic receptor binding assessed by [125I]dexetimide and a simple probe. Eur J Pharmacol 358:207-11
Baidoo, K E; Lin, K S; Zhan, Y et al. (1998) Design, synthesis, and initial evaluation of high-affinity technetium bombesin analogues. Bioconjug Chem 9:218-25
Baidoo, K E; Scheffel, U; Stathis, M et al. (1998) High-affinity no-carrier-added 99mTc-labeled chemotactic peptides for studies of inflammation in vivo. Bioconjug Chem 9:208-17
Kao, C H; Baidoo, K E; Lever, S Z (1997) Validation and application of a solid phase chemistry method for preparation of high effective specific activity technetium-99m radiopharmaceuticals. Nucl Med Biol 24:499-505

Showing the most recent 10 out of 88 publications