Abstract

The overall direction of our program is to develop and apply radioactive tracer technology to the study of chemical processes going on at different sites within the body i.e. to facilitate the study of the in vivo biochemistry of the living human body. The techniques that we have developed in the past and propose to continue to develop in the future help elucidate """"""""biochemical anatomy"""""""", the topography of physicochemical processes, extending the cellular basis of disease to the molecular level. Our program requires multidisciplinary participation of physicians, physicists, chemists, engineers, and computer experts; and is multidepartmental, involving departments in both the Schools of Medicine and Hygiene and Public Health of the Johns Hopkins Medical Institutions. The program provides a focus for investigators in a continuing program oriented toward obtaining new knowledge about the dynamic state of body constituents by the application of a variety of in vivo biochemistry, identifying hyper- or hypoactive states associated with abnormal body functions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA032845-30
Application #
3093473
Study Section
Special Emphasis Panel (SRC (N1))
Project Start
1977-12-01
Project End
1997-02-28
Budget Start
1992-03-16
Budget End
1993-02-28
Support Year
30
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Public Health
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Madar, Igal; Bencherif, Badredin; Lever, John et al. (2007) Imaging delta- and mu-opioid receptors by PET in lung carcinoma patients. J Nucl Med 48:207-13
Lin, Kuo-Shyan; Luu, Andrew; Baidoo, Kwamena E et al. (2005) A new high affinity technetium-99m-bombesin analogue with low abdominal accumulation. Bioconjug Chem 16:43-50
Hardwick, Matthew J; Chen, Ming-Kai; Baidoo, Kwamena et al. (2005) In vivo imaging of peripheral benzodiazepine receptors in mouse lungs: a biomarker of inflammation. Mol Imaging 4:432-8
Chen, Ming-Kai; Baidoo, Kwamena; Verina, Tatyana et al. (2004) Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization. Brain 127:1379-92
Lin, Kuo-Shyan; Luu, Andrew; Baidoo, Kwamena E et al. (2004) A new high affinity technetium analogue of bombesin containing DTPA as a pharmacokinetic modifier. Bioconjug Chem 15:1416-23
Lever, J R; Ilgin, N; Musachio, J L et al. (1998) Autoradiographic and SPECT imaging of cerebral opioid receptors with an iodine-123 labeled analogue of diprenorphine. Synapse 29:172-82
Sanchez-Roa, P M; Wagner Jr, H N; Villemagne, V L et al. (1998) Effects of extracellular acetylcholine on muscarinic receptor binding assessed by [125I]dexetimide and a simple probe. Eur J Pharmacol 358:207-11
Baidoo, K E; Lin, K S; Zhan, Y et al. (1998) Design, synthesis, and initial evaluation of high-affinity technetium bombesin analogues. Bioconjug Chem 9:218-25
Baidoo, K E; Scheffel, U; Stathis, M et al. (1998) High-affinity no-carrier-added 99mTc-labeled chemotactic peptides for studies of inflammation in vivo. Bioconjug Chem 9:208-17
Kao, C H; Baidoo, K E; Lever, S Z (1997) Validation and application of a solid phase chemistry method for preparation of high effective specific activity technetium-99m radiopharmaceuticals. Nucl Med Biol 24:499-505

Showing the most recent 10 out of 88 publications