Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA033620-03
Application #
4691441
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027
Friedman, P N; Chen, X; Bargonetti, J et al. (1993) The p53 protein is an unusually shaped tetramer that binds directly to DNA. Proc Natl Acad Sci U S A 90:3319-23
Bargonetti, J; Manfredi, J J; Chen, X et al. (1993) A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein. Genes Dev 7:2565-74
Prives, C (1993) Doing the right thing: feedback control and p53. Curr Opin Cell Biol 5:214-8
Harper, J E; Manley, J L (1992) Multiple activities of the human splicing factor ASF. Gene Expr 2:19-29
Friedman, P N; Wang, E H; Meerovitch, K et al. (1992) Murine p53 inhibits the function but not the formation of SV40 T antigen hexamers and stimulates T antigen RNA helicase activity. Chromosoma 102:S60-6
Bargonetti, J; Reynisdottir, I; Friedman, P N et al. (1992) Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53. Genes Dev 6:1886-98
Huber, P W; Morii, T; Mei, H Y et al. (1991) Structural polymorphism in the major groove of a 5S RNA gene complements the zinc finger domains of transcription factor IIIA. Proc Natl Acad Sci U S A 88:10801-5
Bargonetti, J; Friedman, P N; Kern, S E et al. (1991) Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication. Cell 65:1083-91
Fukasawa, K; Sakoulas, G; Pollack, R E et al. (1991) Excess wild-type p53 blocks initiation and maintenance of simian virus 40 transformation. Mol Cell Biol 11:3472-83
Prives, C; Bargonetti, J; Friedman, P N et al. (1991) Functional consequences of the interactions of the p53 tumor suppressor protein and SV40 large tumor antigen. Cold Spring Harb Symp Quant Biol 56:227-35

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