Abstract

This program project is an integrated interdisciplinary program which deals with the clinical application of monoclonal antibodies (MoAbs) for the in vivo detection and therapy of cancer. The program brings together basic scientists and clinicians in the disciplines of oncology, immunology, cell biology, nuclear medicine, radiation therapy, pathology, molecular biology and biochemistry. Specific cancers studied will be lymphoma, colorectal carcinoma, and lung cancer, with an emphasis on the application of 111Indium and 90 Yttrium-labeled moAbs. In lymphoma, use of antiidiotype MoAbs for passive and active immunotherapy will be emphasized. Additional studies will include immunologic and molecular characterization of cross-reactive idiotypes expressed by B cell malignancies and in vitro immunization for the production of human anti-tumor MoAbs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA037497-07
Application #
3093633
Study Section
Special Emphasis Panel (SRC)
Project Start
1984-08-15
Project End
1992-11-30
Budget Start
1991-06-10
Budget End
1992-11-30
Support Year
7
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Sidney Kimmel Cancer Center
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92121

  Publications

White, C A; Halpern, S E; Parker, B A et al. (1996) Radioimmunotherapy of relapsed B-cell lymphoma with yttrium 90 anti-idiotype monoclonal antibodies. Blood 87:3640-9
Brams, P; Royston, I; Boerner, P (1993) In vitro priming of human lymphocytes. II. Induction of antigen-specific IgG responses by repeated antigen stimulation. Hum Antibodies Hybridomas 4:57-65
Lu, E W; Bustria, A T; Royston, I et al. (1993) Factors affecting production of antibodies to prostate antigens by in vitro-primed human splenocytes. Hybridoma 12:381-9
Brams, P; Royston, I; Boerner, P (1993) In vitro priming of human lymphocytes. I. IL-2 and IL-4 requirements. Hum Antibodies Hybridomas 4:47-56
Swisher, E M; Shawler, D L; Collins, H A et al. (1991) Expression of shared idiotypes in chronic lymphocytic leukemia and small lymphocytic lymphoma. Blood 77:1977-82
Boerner, P; Lafond, R; Lu, W Z et al. (1991) Production of antigen-specific human monoclonal antibodies from in vitro-primed human splenocytes. J Immunol 147:86-95
Roudier, J; Silverman, G J; Chen, P P et al. (1990) Intraclonal diversity in the VH genes expressed by CD5- chronic lymphocytic leukemia-producing pathologic IgM rheumatoid factor. J Immunol 144:1526-30
Parker, B A; Vassos, A B; Halpern, S E et al. (1990) Radioimmunotherapy of human B-cell lymphoma with 90Y-conjugated antiidiotype monoclonal antibody. Cancer Res 50:1022s-1028s
Miller, R A; Hart, S; Samoszuk, M et al. (1989) Shared idiotypes expressed by human B-cell lymphomas. N Engl J Med 321:851-7
Leonard, J E; Grothaus, C D; Taetle, R (1988) Ricin binding and protein synthesis inhibition in human hematopoietic cell lines. Blood 72:1357-63

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