Abstract

An interdisciplinary effort is proposed to develop high-data-rate digital microscopes for diagnostic work in the clinical pathology laboratory. Applications in clinical cancer cytology, tumor pathology, tumor therapy response predictive assays, and immunopathology require the high-resolution scanning of extended areas. Four projects are planned involving the Department of Pathology, the Optical Design Section, the Laser Physics Section, and the Microprocessor Section of the Optical Sciences Center, and faculty from the University of Heidelberg. The ultrafast laser scanner microscope will be taken into operation in clinical pathology, and operational software will be developed. A very-high-data-rate fluorescence scanner capable of recording 50,000 cells/minute, with novel optics optimized for high light collection will be designed. A module to measure low-light-level fluorescence and phosphorescence in cells and itissues at cryogenic temperatures will be designed. The multi-microprocessor system """"""""Heidelberg POLYP"""""""" grant will be transferred into this program project. (3)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA038548-03
Application #
3093679
Study Section
(SRC)
Project Start
1985-01-01
Project End
1987-12-31
Budget Start
1987-01-01
Budget End
1987-12-31
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Arizona
Department
Type
Schools of Arts and Sciences
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85722

  Publications

Bartels, P H; Thompson, D; Weber, J E (1992) Expert systems in histopathology. IV. The management of uncertainty. Anal Quant Cytol Histol 14:1-13
Bartels, P H (1992) Computer-generated diagnosis and image analysis. An overview. Cancer 69:1636-8
Bartels, P H; Thompson, D; Weber, J E (1992) Expert systems in histopathology. V. DS theory, certainty factors and possibility theory. Anal Quant Cytol Histol 14:165-74
Wied, G L; Bartels, P H; Bibbo, M et al. (1989) Image analysis in quantitative cytopathology and histopathology. Hum Pathol 20:549-71
Bartels, P H (1989) The diagnostic pattern in histopathology. Am J Clin Pathol 91:S7-13
Bartels, P H; Weber, J E; Duckstein, L (1988) Machine learning in quantitative histopathology. Anal Quant Cytol Histol 10:299-306
Graham, A R; Paplanus, S H; Bartels, P H (1988) Micromorphometry of colonic lesions. Lab Invest 59:397-402
Shack, R V; Bartels, P H; Buchroeder, R A et al. (1987) Design for a fast fluorescence laser scanning microscope. Anal Quant Cytol Histol 9:509-20
Paplanus, S H; Graham, A R (1987) Morphometry in surgical pathology. Anal Quant Cytol Histol 9:455-8
Paplanus, S H; Graham, A R; Layton, J M et al. (1985) Statistical histometry in the diagnostic assessment of tissue sections. Anal Quant Cytol 7:32-7