This project proposes to compare the data generated from manofluorographic studies of oropharyngeal swallow with that collected with modified barium swallow (MBS) and biomechanical analysis. Currently, many patients receive videofluoroscopic examination of swallow (MBS) which provides information on the movement of food and the movement of structures. However, no pressure information is collected, and swallowing is a pressure phenomenon. Also, no measures of structural movement are made. We are hypothesizing that patients who have undergone particular types of head and neck cancer surgical procedures may be better evaluated with combined videofluoroscopy and manometry, or with biomechanical analysis than with modified barium swallow, since the more objective measures from biomechanical analysis and/or manofluorography (which also assesses pressure) may provide us with information which is more revealing regarding the nature of their altered swallow physiology and the effects of treatment strategies. The swallow physiology of 60 surgically treated head and neck cancer patients will be evaluated using simultaneous manometry and fluoroscopy (manofluorography). Data from the combined procedures will be analyzed with manofluorography while the video recording of fluoroscopy will be analyzed as a modified barium swallow and biomechanically. Results of each analysis will be compared to determine which technique provides most information regarding the swallowing ability of particular types of cancer patients, and to determine whether objective measures provide us with additional information over observations of swallow.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA040007-06A1
Application #
3807313
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Type
DUNS #
City
Evanston
State
IL
Country
United States
Zip Code
60201
Logemann, Jerilyn A (2014) Critical Factors in the Oral Control Needed for Chewing and Swallowing. J Texture Stud 45:173-179
Pauloski, Barbara Roa; Logemann, Jerilyn A; Rademaker, Alfred W et al. (2013) Effects of enhanced bolus flavors on oropharyngeal swallow in patients treated for head and neck cancer. Head Neck 35:1124-31
Pauloski, Barbara Roa; Rademaker, Alfred W; Lazarus, Cathy et al. (2009) Relationship between manometric and videofluoroscopic measures of swallow function in healthy adults and patients treated for head and neck cancer with various modalities. Dysphagia 24:196-203
Logemann, Jeri A; Pauloski, Barbara Roa; Rademaker, Alfred W et al. (2008) Swallowing disorders in the first year after radiation and chemoradiation. Head Neck 30:148-58
Pauloski, Barbara Roa; Rademaker, Alfred W; Logemann, Jerilyn A et al. (2006) Relationship between swallow motility disorders on videofluorography and oral intake in patients treated for head and neck cancer with radiotherapy with or without chemotherapy. Head Neck 28:1069-76
Daggett, Alicia; Logemann, Jeri; Rademaker, Alfred et al. (2006) Laryngeal penetration during deglutition in normal subjects of various ages. Dysphagia 21:270-4
Smith, Christina H; Logemann, Jeri A; Burghardt, Wesley R et al. (2006) Oral and oropharyngeal perceptions of fluid viscosity across the age span. Dysphagia 21:209-17
Logemann, Jeri A; Rademaker, Alfred W; Pauloski, Barbara Roa et al. (2006) Site of disease and treatment protocol as correlates of swallowing function in patients with head and neck cancer treated with chemoradiation. Head Neck 28:64-73
Logemann, Jeri A; Williams, Rohan B; Rademaker, Alfred et al. (2005) The relationship between observations and measures of oral and pharyngeal residue from videofluorography and scintigraphy. Dysphagia 20:226-31
Waters, Teresa M; Logemann, Jeri A; Pauloski, Barbara Roa et al. (2004) Beyond efficacy and effectiveness: conducting economic analyses during clinical trials. Dysphagia 19:109-19

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