Abstract

The goal of the Cell and Molecular Biology Core is to provide services and consultative expertise to the Program Project principal investigators in a timely and cost-effective manner. the impetus for starting this core is the recognition of the growing role of molecular biology in the Program Project grant. The essential services offered will be the isolation and characterization of multiple plasmids (to be used by 4 of the 5 projects), mycoplasma testing of cultured cells, and retrieval and storage of breast tumors from our and outlying hospitals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA040011-11
Application #
6102220
Study Section
Project Start
1995-08-01
Project End
1998-07-31
Budget Start
Budget End
Support Year
11
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Type
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033

  Publications

Hurst, Douglas R; Welch, Danny R (2007) A MSC-ing link in metastasis? Nat Med 13:1289-91
Manni, A; Wechter, R; Verderame, M F et al. (1998) Cooperativity between the polyamine pathway and HER-2neu in transformation of human mammary epithelial cells in culture: role of the MAPK pathway. Int J Cancer 76:563-70
Phillips, K K; White, A E; Hicks, D J et al. (1998) Correlation between reduction of metastasis in the MDA-MB-435 model system and increased expression of the Kai-1 protein. Mol Carcinog 21:111-20
McGary, C T; Pan, Y C; Michel, H et al. (1997) Elevated expression of the neutrophil calcium-binding protein, MRP-14, in metastasis-enhancing neutrophils. Anticancer Res 17:1-6
Masamura, S; Santner, S J; Gimotty, P et al. (1997) Mechanism for maintenance of high breast tumor estradiol concentrations in the absence of ovarian function: role of very high affinity tissue uptake. Breast Cancer Res Treat 42:215-26
Manni, A; Wechter, R; Gilmour, S et al. (1997) Ornithine decarboxylase over-expression stimulates mitogen-activated protein kinase and anchorage-independent growth of human breast epithelial cells. Int J Cancer 70:175-82
Welch, D R (1997) Technical considerations for studying cancer metastasis in vivo. Clin Exp Metastasis 15:272-306
Wei, L L; Norris, B M; Baker, C J (1997) An N-terminally truncated third progesterone receptor protein, PR(C), forms heterodimers with PR(B) but interferes in PR(B)-DNA binding. J Steroid Biochem Mol Biol 62:287-97
Phillips, K K; Welch, D R; Miele, M E et al. (1996) Suppression of MDA-MB-435 breast carcinoma cell metastasis following the introduction of human chromosome 11. Cancer Res 56:1222-7
Manni, A; Buckwalter, E; Etindi, R et al. (1996) Induction of a less aggressive breast cancer phenotype by protein kinase C-alpha and -beta overexpression. Cell Growth Differ 7:1187-98

Showing the most recent 10 out of 96 publications