The International Bone Marrow Transplant Registry (IBMTR) is a collaborative study group that has been conducting research for the past 20 years in an effort to improve the safety and success of bone marrow transplantation for the treatment of a variety of otherwise largely incurable diseases. At present nearly 200 (more than 75% of all) transplant teams in the US and abroad voluntarily contribute detailed information regarding their consecutive transplant cases to the IBMTR on uniform reporting forms. Data for more than 10,000 recipients of allogeneic and syngeneic transplants are presently stored in the IBMTR database. Reporting forms are being prepared and data collection for autologous bone marrow transplants will be initiated in 1990. In this five-year Program Project renewal application, the Advisory Committees of the IBMTR and the North American Autologous Bone Marrow Transplant Registry (NAABMTR) request support for a statistical core component that is required by and shared solely within the proposed research program. Support also is requested to conduct studies designed to address key questions that would be difficult or impossible for single institutions to undertake but can be investigated using pooled data from multiple centers. Project I is focused on critical but unresolved issues in allogeneic bone marrow transplantation for both common and rare diseases such as leukemia, myelodysplastic syndromes and Fanconi anemia. Project II addresses immunogenetic and management problems in allogeneic bone marrow transplantation such as HLA-matched and mismatched related and unrelated donor selection, graft-versus-host disease, graft-versus- leukemia reactions and late effects of bone marrow transplantation. Project III examines critical but unresolved issues in autologous bone marrow transplants for acute leukemia, lymphoma, neuroblastoma and breast cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA040053-06
Application #
3093786
Study Section
Special Emphasis Panel (SRC (J1))
Project Start
1986-03-15
Project End
1994-02-28
Budget Start
1991-03-05
Budget End
1992-02-29
Support Year
6
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Metayer, Catherine; Curtis, Rochelle E; Vose, Julie et al. (2003) Myelodysplastic syndrome and acute myeloid leukemia after autotransplantation for lymphoma: a multicenter case-control study. Blood 101:2015-23
Lee, Stephanie J; Klein, John P; Barrett, A John et al. (2002) Severity of chronic graft-versus-host disease: association with treatment-related mortality and relapse. Blood 100:406-14
Berry, Donald A; Broadwater, Gloria; Klein, John P et al. (2002) High-dose versus standard chemotherapy in metastatic breast cancer: comparison of Cancer and Leukemia Group B trials with data from the Autologous Blood and Marrow Transplant Registry. J Clin Oncol 20:743-50
Lazarus, H M; Loberiza Jr, F R; Zhang, M J et al. (2001) Autotransplants for Hodgkin's disease in first relapse or second remission: a report from the autologous blood and marrow transplant registry (ABMTR). Bone Marrow Transplant 27:387-96
Vose, J M; Zhang, M J; Rowlings, P A et al. (2001) Autologous transplantation for diffuse aggressive non-Hodgkin's lymphoma in patients never achieving remission: a report from the Autologous Blood and Marrow Transplant Registry. J Clin Oncol 19:406-13
Anderlini, P; Rizzo, J D; Nugent, M L et al. (2001) Peripheral blood stem cell donation: an analysis from the International Bone Marrow Transplant Registry (IBMTR) and European Group for Blood and Marrow Transplant (EBMT) databases. Bone Marrow Transplant 27:689-92
Filipovich, A H; Stone, J V; Tomany, S C et al. (2001) Impact of donor type on outcome of bone marrow transplantation for Wiskott-Aldrich syndrome: collaborative study of the International Bone Marrow Transplant Registry and the National Marrow Donor Program. Blood 97:1598-603
Vahdat, L; Papadopoulos, K; Lange, D et al. (2001) Reduction of paclitaxel-induced peripheral neuropathy with glutamine. Clin Cancer Res 7:1192-7
Zhang, M J; Klein, J P (2001) Confidence bands for the difference of two survival curves under proportional hazards model. Lifetime Data Anal 7:243-54
Davies, S M; Ramsay, N K; Klein, J P et al. (2000) Comparison of preparative regimens in transplants for children with acute lymphoblastic leukemia. J Clin Oncol 18:340-7

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