Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA041085-01
Application #
3093829
Study Section
Cancer Special Program Advisory Committee (CAK)
Project Start
1986-02-01
Project End
1991-01-31
Budget Start
1986-02-01
Budget End
1987-01-31
Support Year
1
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92037
Felez, J; Chanquia, C J; Levin, E G et al. (1991) Binding of tissue plasminogen activator to human monocytes and monocytoid cells. Blood 78:2318-27
Ruf, W; Edgington, T S (1991) An anti-tissue factor monoclonal antibody which inhibits TF.VIIa complex is a potent anticoagulant in plasma. Thromb Haemost 66:529-33
Ruf, W; Kalnik, M W; Lund-Hansen, T et al. (1991) Characterization of factor VII association with tissue factor in solution. High and low affinity calcium binding sites in factor VII contribute to functionally distinct interactions. J Biol Chem 266:15719-25
Ruf, W; Rehemtulla, A; Morrissey, J H et al. (1991) Phospholipid-independent and -dependent interactions required for tissue factor receptor and cofactor function. J Biol Chem 266:2158-66
Fan, S T; Edgington, T S (1991) Coupling of the adhesive receptor CD11b/CD18 to functional enhancement of effector macrophage tissue factor response. J Clin Invest 87:50-7
Fan, S T; Glasebrook, A L; Edgington, T S (1990) Clonal analysis of CD4+ T helper cell subsets that induce the monocyte procoagulant response. Cell Immunol 128:52-62
Felez, J; Miles, L A; Plescia, J et al. (1990) Regulation of plasminogen receptor expression on human monocytes and monocytoid cell lines. J Cell Biol 111:1673-83
Altieri, D C; Edgington, T S (1990) Identification of effector cell protease receptor-1. A leukocyte-distributed receptor for the serine protease factor Xa. J Immunol 145:246-53
Altieri, D C; Wiltse, W L; Edgington, T S (1990) Signal transduction initiated by extracellular nucleotides regulates the high affinity ligand recognition of the adhesive receptor CD11b/CD18. J Immunol 145:662-70
Mackman, N; Fowler, B J; Edgington, T S et al. (1990) Functional analysis of the human tissue factor promoter and induction by serum. Proc Natl Acad Sci U S A 87:2254-8

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