The objectives of the Nutrition Core are to consolidate resources and provide support needed for adequate nutrition, body composition and physical activity assessment in the associated projects, and to conduct research required for continuing refinement of related methodology appropriate to cancer prevention control projects.
Specific aims i nclude 1) supervision of the design and collection of all dietary and physical activity data in close collaboration with the Adherence Core; 2) Maintenance and ongoing development of appropriate food composition data bases; 3) Reduction of dietary data (coding and conversion to nutrients, food groups, or compounds of interest; 4) Provision of data to project investigators, working in close collaboration with the Biometry Core; 5) Consultation with project investigators regarding interpretation of results; 6) Maintenance of quality control procedures for dietary and physical activity, data collection, coding, and analysis; and 7) Methodologic investigation in support of the projects. The two colon cancer prevention intervention projects (Fiber, Ursodeoxcholic Acid) included in this application require ongoing nutritional status and dietary assessment components for eligibility, and to evaluate confounding and interacting nutrients. Dietary and physical activity data will be collected to monitor time trends, and to assess their relation to polyp recurrence. The Genetic Alterations study will require dietary intake assessment data and analysis in support of specific aims regarding the relation of diet to genetic alterations In polyps. The common focus on colon polyps and the design of the three projects permit consolidation of efforts regarding dietary evaluation and physical activity, and will permit cross-project analyses which will extend the utility of each project's results. A working framework in the form of a proposed model for nutrient interactions with the promotion and progression of small adenomas has been developed to guide the collection and analysis of dietary data. The Arizona Food Frequency Questionnaire and dietary intake records will be used to determine eligibility and monitor subjects in the projects. A scannable physical activity questionnaire, developed from our current questionnaire, will be used to monitor activity patterns throughout the trials.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA041108-10
Application #
5207299
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Lance, Peter; Alberts, David S; Thompson, Patricia A et al. (2017) Colorectal Adenomas in Participants of the SELECT Randomized Trial of Selenium and Vitamin E for Prostate Cancer Prevention. Cancer Prev Res (Phila) 10:45-54
Hibler, Elizabeth A; Sardo Molmenti, Christine L; Dai, Qi et al. (2016) Physical activity, sedentary behavior, and vitamin D metabolites. Bone 83:248-255
Thompson, Patricia A; Ashbeck, Erin L; Roe, Denise J et al. (2016) Selenium Supplementation for Prevention of Colorectal Adenomas and Risk of Associated Type 2 Diabetes. J Natl Cancer Inst 108:
Jacobs, Elizabeth T; Haussler, Mark R; Alberts, David S et al. (2016) Association between Circulating Vitamin D Metabolites and Fecal Bile Acid Concentrations. Cancer Prev Res (Phila) 9:589-97
Liu, Lin; Messer, Karen; Baron, John A et al. (2016) A prognostic model for advanced colorectal neoplasia recurrence. Cancer Causes Control 27:1175-85
Thompson, Patricia A; Ashbeck, Erin L; Roe, Denise J et al. (2016) Celecoxib for the Prevention of Colorectal Adenomas: Results of a Suspended Randomized Controlled Trial. J Natl Cancer Inst 108:
Hibler, Elizabeth A; Klimentidis, Yann C; Jurutka, Peter W et al. (2015) CYP24A1 and CYP27B1 Polymorphisms, Concentrations of Vitamin D Metabolites, and Odds of Colorectal Adenoma Recurrence. Nutr Cancer 67:1131-41
Minasian, Lori M; Tangen, Catherine M; Wickerham, D Lawrence (2015) Ongoing Use of Data and Specimens From National Cancer Institute-Sponsored Cancer Prevention Clinical Trials in the Community Clinical Oncology Program. Semin Oncol 42:748-63
Bea, Jennifer W; Jurutka, Peter W; Hibler, Elizabeth A et al. (2015) Concentrations of the vitamin D metabolite 1,25(OH)2D and odds of metabolic syndrome and its components. Metabolism 64:447-59
Molmenti, Christine L Sardo; Hibler, Elizabeth A; Ashbeck, Erin L et al. (2014) Sedentary behavior is associated with colorectal adenoma recurrence in men. Cancer Causes Control 25:1387-95

Showing the most recent 10 out of 149 publications