The overall goal of this Program Project is to greatly expand our understanding of the clinical significance of chromosome change in human cancers. Our approach will be to correlate laboratory studies with important clinical features in a multidisciplinary research effort. Experts in the areas of cancer cytogenetics, molecular biology, medical oncology, surgery, cell culture, tumor pathology, and biostatistics have been assembled and will focus on studies of: clinical correlations of chromosome change and cytogenetic and molecular biologic analysis of acquired drug resistance.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (SRC (Q2))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Arizona
Schools of Medicine
United States
Zip Code
Nelson, M A; Radmacher, M D; Simon, R et al. (2000) Chromosome abnormalities in malignant melanoma: clinical significance of nonrandom chromosome abnormalities in 206 cases. Cancer Genet Cytogenet 122:101-9
Simon, R; Desper, R; Papadimitriou, C H et al. (2000) Chromosome abnormalities in ovarian adenocarcinoma: III. Using breakpoint data to infer and test mathematical models for oncogenesis. Genes Chromosomes Cancer 28:106-20
Taetle, R; Aickin, M; Yang, J M et al. (1999) Chromosome abnormalities in ovarian adenocarcinoma: I. Nonrandom chromosome abnormalities from 244 cases. Genes Chromosomes Cancer 25:290-300
Taetle, R; Aickin, M; Panda, L et al. (1999) Chromosome abnormalities in ovarian adenocarcinoma: II. Prognostic impact of nonrandom chromosome abnormalities in 244 cases. Genes Chromosomes Cancer 25:46-52
Meloni-Ehrig, A M; Chen, Z; Guan, X Y et al. (1999) Identification of a ring chromosome in a myxoid malignant fibrous histiocytoma with chromosome microdissection and fluorescence in situ hybridization. Cancer Genet Cytogenet 109:81-5
Ozisik, Y Y; Meloni, A M; Spanier, S S et al. (1998) Deletion 1p in a low-grade chondrosarcoma in a patient with Ollier disease. Cancer Genet Cytogenet 105:128-33
Kline, R M; Oseas, R S; Jolley, S G et al. (1997) Leptomeningeal metastasis from a paraspinal rhabdomyosarcoma with a der(13)t(1;13)(q23;q32) in a 14-month-old boy. Cancer Genet Cytogenet 98:97-101
Kingsley, K L; Peier, A M; Meloni-Ehrig, A M et al. (1997) Cytogenetic findings in a bladder chondrosarcoma. Cancer Genet Cytogenet 96:183-4
Paine-Murrieta, G D; Taylor, C W; Curtis, R A et al. (1997) Human tumor models in the severe combined immune deficient (scid) mouse. Cancer Chemother Pharmacol 40:209-14
Thompson, F H; Taetle, R; Trent, J M et al. (1997) Band 1p36 abnormalities and t(1;17) in ovarian carcinoma. Cancer Genet Cytogenet 96:106-10

Showing the most recent 10 out of 133 publications