Abstract

Although a paucity of information exists regarding cytogenetic alterations in most human solid tumors, particularly little is known about cancers of the prostate, kidney, and testes. This project will focus upon identifying both primary and secondary chromosome changes in an attempt to correlate recognized chromosome alterations with clinical features important to these cancers. With the significant clinical resources available to this project, our documented expertise in tumor cytogenetics, and our recent advances in cell culture techniques, we should be able to provide important new information regarding the karyotypic profile of these important cancers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA041183-06
Application #
3795160
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of Arizona
Department
Type
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721

  Publications

Nelson, M A; Radmacher, M D; Simon, R et al. (2000) Chromosome abnormalities in malignant melanoma: clinical significance of nonrandom chromosome abnormalities in 206 cases. Cancer Genet Cytogenet 122:101-9
Simon, R; Desper, R; Papadimitriou, C H et al. (2000) Chromosome abnormalities in ovarian adenocarcinoma: III. Using breakpoint data to infer and test mathematical models for oncogenesis. Genes Chromosomes Cancer 28:106-20
Taetle, R; Aickin, M; Yang, J M et al. (1999) Chromosome abnormalities in ovarian adenocarcinoma: I. Nonrandom chromosome abnormalities from 244 cases. Genes Chromosomes Cancer 25:290-300
Taetle, R; Aickin, M; Panda, L et al. (1999) Chromosome abnormalities in ovarian adenocarcinoma: II. Prognostic impact of nonrandom chromosome abnormalities in 244 cases. Genes Chromosomes Cancer 25:46-52
Meloni-Ehrig, A M; Chen, Z; Guan, X Y et al. (1999) Identification of a ring chromosome in a myxoid malignant fibrous histiocytoma with chromosome microdissection and fluorescence in situ hybridization. Cancer Genet Cytogenet 109:81-5
Ozisik, Y Y; Meloni, A M; Spanier, S S et al. (1998) Deletion 1p in a low-grade chondrosarcoma in a patient with Ollier disease. Cancer Genet Cytogenet 105:128-33
Kline, R M; Oseas, R S; Jolley, S G et al. (1997) Leptomeningeal metastasis from a paraspinal rhabdomyosarcoma with a der(13)t(1;13)(q23;q32) in a 14-month-old boy. Cancer Genet Cytogenet 98:97-101
Kingsley, K L; Peier, A M; Meloni-Ehrig, A M et al. (1997) Cytogenetic findings in a bladder chondrosarcoma. Cancer Genet Cytogenet 96:183-4
Paine-Murrieta, G D; Taylor, C W; Curtis, R A et al. (1997) Human tumor models in the severe combined immune deficient (scid) mouse. Cancer Chemother Pharmacol 40:209-14
Thompson, F H; Taetle, R; Trent, J M et al. (1997) Band 1p36 abnormalities and t(1;17) in ovarian carcinoma. Cancer Genet Cytogenet 96:106-10

Showing the most recent 10 out of 133 publications