Abstract

MicroRNAs are predicted to regulate a majority of genes in human cells and both overexpression and loss of expression of some miRNAs are correlated with malignant phenotypes in different cancer cells. A decrease in miRNA activity is most commonly observed and may be important for the plasticity of tumor cells to undergo transitions between differentiation states and to grow in different niches.
In Aim 1 of this Project we plan to investigate

Public Health Relevance

Decreases in miRNA regulation are commonly observed in malignant cells. This probably confers plasticity to cancer cells permitting a greater range of developmental states and more diverse responses to stresses. Integrating the current understanding of miRNA regulation into the chain of events in vivo that results in a malignant cell is important. A greater understanding of the roles in cancer of the large family of non-coding RNAs could provide new opportunities for diagnosis and treatment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA042063-26A1
Application #
8299784
Study Section
Special Emphasis Panel (ZCA1-RPRB-O (J1))
Project Start
1997-05-01
Project End
2017-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
26
Fiscal Year
2012
Total Cost
$818,083
Indirect Cost
$538,102

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Gao, Ang; Shrinivas, Krishna; Lepeudry, Paul et al. (2018) Evolution of weak cooperative interactions for biological specificity. Proc Natl Acad Sci U S A 115:E11053-E11060
Dubbury, Sara J; Boutz, Paul L; Sharp, Phillip A (2018) CDK12 regulates DNA repair genes by suppressing intronic polyadenylation. Nature 564:141-145
Parisi, Tiziana; Balsamo, Michele; Gertler, Frank et al. (2018) The Rb tumor suppressor regulates epithelial cell migration and polarity. Mol Carcinog 57:1640-1650
Sabari, Benjamin R; Dall'Agnese, Alessandra; Boija, Ann et al. (2018) Coactivator condensation at super-enhancers links phase separation and gene control. Science 361:
Chiu, Anthony C; Suzuki, Hiroshi I; Wu, Xuebing et al. (2018) Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP. Mol Cell 69:648-663.e7
Mori, Munemasa; Hazan, Renin; Danielian, Paul S et al. (2017) Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis. Nat Commun 8:15857
Braun, Christian J; Stanciu, Monica; Boutz, Paul L et al. (2017) Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma. Cancer Cell 32:411-426.e11
Tammela, Tuomas; Sanchez-Rivera, Francisco J; Cetinbas, Naniye Malli et al. (2017) A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma. Nature 545:355-359
Sasi, Nanda Kumar; Bhutkar, Arjun; Lanning, Nathan J et al. (2017) DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways. Neoplasia 19:439-450
JnBaptiste, Courtney K; Gurtan, Allan M; Thai, Kevin K et al. (2017) Corrigendum: Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family. Genes Dev 31:1066

Showing the most recent 10 out of 218 publications