The goal of this project is to clinically use magnetic resonance imaging (MRI) to control and monitor this thermal therapeutic procedures proposed in the clinical projects in this program. It has been shown that MRI can be effective for visualizing temperature changes in tissues associated with the absorption of non-ionizing therapeutic applications, but are generally in the changes 0.5-1.0 degrees Centigrade, 0.5-1.0 cc voxel size, and 6-20 seconds measurement acquisition time. These resolution ranges imply that MRI can play an important role as a non- invasive tool in the development and application of thermal therapies. In particular, we pose the hypothesis that: Magnetic resonance imaging can be used to control the energy rate of distribution (ARD) and monitor temperatures during thermal therapeutic procedures involving large tumor volumes. We will test these hypothesis using the following specific aims: 1. Develop robust MR thermal imaging techniques for in vivo applications. 2. Develop MRI based feedback control algorithms for the energy absorption rate distribution. Demonstrate ARD control and temperature monitoring in patients having tumors of the lower extremity, based on temperature data acquired with MR chemical shift and/or effective diffusion constant images. Demonstrate ARD control and temperatures monitoring in patients having tumors in the lower abdomen and pelvis with temperature resolution of 0.75-1.25 degrees Centigrade in 1 cc voxels.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
Project #
Application #
Study Section
Subcommittee E - Prevention &Control (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Duke University
United States
Zip Code
Stauffer, Paul R; van Rhoon, Gerard C (2016) Overview of bladder heating technology: matching capabilities with clinical requirements. Int J Hyperthermia 32:407-16
Juang, Titania; Stauffer, Paul R; Craciunescu, Oana A et al. (2014) Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer. Int J Hyperthermia 30:176-83
Inman, Brant A; Stauffer, Paul R; Craciunescu, Oana A et al. (2014) A pilot clinical trial of intravesical mitomycin-C and external deep pelvic hyperthermia for non-muscle-invasive bladder cancer. Int J Hyperthermia 30:171-5
Angele, Martin K; Albertsmeier, Markus; Prix, Niclas J et al. (2014) Effectiveness of regional hyperthermia with chemotherapy for high-risk retroperitoneal and abdominal soft-tissue sarcoma after complete surgical resection: a subgroup analysis of a randomized phase-III multicenter study. Ann Surg 260:749-54; discussion 754-6
Zagar, Timothy M; Vujaskovic, Zeljko; Formenti, Silvia et al. (2014) Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer. Int J Hyperthermia 30:285-94
Viglianti, Benjamin L; Dewhirst, Mark W; Boruta, R J et al. (2014) Systemic anti-tumour effects of local thermally sensitive liposome therapy. Int J Hyperthermia 30:385-92
Cao, Yiting; Eble, Joseph M; Moon, Ejung et al. (2013) Tumor cells upregulate normoxic HIF-1? in response to doxorubicin. Cancer Res 73:6230-42
Boss, M Keara; Muradyan, N; Thrall, D E (2013) DCE-MRI: a review and applications in veterinary oncology. Vet Comp Oncol 11:87-100
Oliveira, Tiago R; Stauffer, Paul R; Lee, Chen-Ting et al. (2013) Magnetic fluid hyperthermia for bladder cancer: a preclinical dosimetry study. Int J Hyperthermia 29:835-44
Dewhirst, Mark W; Landon, Chelsea D; Hofmann, Christina L et al. (2013) Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes. Surg Oncol Clin N Am 22:545-61

Showing the most recent 10 out of 227 publications