The overall goals of this core is to provide a centralized resource for acquisition, logging, processing, storage and analysis of plasma samples and tissues biopsies.
Specific aims of this core are: 1) To provide a centralized facility to support standardized ancillary studies for several human clinical trials, canine trial, and rodent studies and examine tissue and plasma-based parameters related to tumor hypoxia, angiogenesis, and acidosis. 2) Plasma/serum samples will be analyzed for key markers of hypoxia and angiogenic activity. Tissues will be used for for immunohistochemical evaluation of the hypoxia-regulated protein, CAIX (carbonic anhydrase, isoform IX), microvessel density, and in situ measurement of tissue lactate concentrations using bioluminescence imaging. These efforts will support ancillary studies of five human trials in Project 5, canine trial in Project 4 and rodent studies in Project 3. 3) Gene expression analysis will also be used to assess changes in gene expression early in the course of therapy to ascertain which types of genes are altered in response to therapies involving combinations of hyperthermia with radiotherapy and/or chemotherapy. Gene array analysis will be performed on tissues obtained from human and canine patients enrolled in clinical trials. Statistical analysis of these results will be done in the Biostatistics and Information Sciences core. This core will be directed by Dr. Vujaskovic, who already coordinates these activities on a regularly scheduled basis. The core will provide the necessary infrastructure to make these essential efforts in the program cost-effective, streamlined, and standardized.
|Stauffer, Paul R; van Rhoon, Gerard C (2016) Overview of bladder heating technology: matching capabilities with clinical requirements. Int J Hyperthermia 32:407-16|
|Juang, Titania; Stauffer, Paul R; Craciunescu, Oana A et al. (2014) Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer. Int J Hyperthermia 30:176-83|
|Inman, Brant A; Stauffer, Paul R; Craciunescu, Oana A et al. (2014) A pilot clinical trial of intravesical mitomycin-C and external deep pelvic hyperthermia for non-muscle-invasive bladder cancer. Int J Hyperthermia 30:171-5|
|Angele, Martin K; Albertsmeier, Markus; Prix, Niclas J et al. (2014) Effectiveness of regional hyperthermia with chemotherapy for high-risk retroperitoneal and abdominal soft-tissue sarcoma after complete surgical resection: a subgroup analysis of a randomized phase-III multicenter study. Ann Surg 260:749-54; discussion 754-6|
|Zagar, Timothy M; Vujaskovic, Zeljko; Formenti, Silvia et al. (2014) Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer. Int J Hyperthermia 30:285-94|
|Viglianti, Benjamin L; Dewhirst, Mark W; Boruta, R J et al. (2014) Systemic anti-tumour effects of local thermally sensitive liposome therapy. Int J Hyperthermia 30:385-92|
|Dewhirst, Mark W; Landon, Chelsea D; Hofmann, Christina L et al. (2013) Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes. Surg Oncol Clin N Am 22:545-61|
|Oliveira, Tiago R; Stauffer, Paul R; Lee, Chen-Ting et al. (2013) Preclinical Dosimetry of Magnetic Fluid Hyperthermia for Bladder Cancer. Proc SPIE Int Soc Opt Eng 8584:1656985|
|van Rhoon, Gerard C; Samaras, Theodoros; Yarmolenko, Pavel S et al. (2013) CEM43°C thermal dose thresholds: a potential guide for magnetic resonance radiofrequency exposure levels? Eur Radiol 23:2215-27|
|Kok, H Petra; Gellermann, Johanna; van den Berg, Cornelis A T et al. (2013) Thermal modelling using discrete vasculature for thermal therapy: A review. Int J Hyperthermia 29:336-45|
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