This is a proposal to conduct a case-control study to test the hypothesis that infection with human papilloma virus (HPV) is related to an increased risk of anogenital cancers. The study will be conducted primarily in three counties of Western Washington that are covered by the population-based Cancer Surveillance System (CSS), a tumor registry that participates in the Surveillance Epidemiology and End Results Program (SEER) of the National Cancer Institute. (Penile, urethral, and vaginal cancers from ten additional counties will be included to provide a sufficient sample size.) All men and women aged 18-74 with the following diagnoses will be identified and invited to participate: invasive cancer of the cervix (375 cases); anal and perianal cancer (130 cases); vulvar cancer (200 cases); penile cancer (100 cases); urethral cancer (80 cases); and cancer of the vagina (80 cases). Eligible subjects will be all incident cases from the years 1986-1991 for cervical, anal, perianal, and vulvar cancer, and years 1981-1991 for penile, urethral, and vaginal cancer. Cases and appropriate controls will be interviewed regarding a history of sexually-transmitted diseases, as well as other known risk factors for each specific site. Tissue specimens (or Pap smears) will be collected from each case and from an appropriate control group. Theses samples will be examined using molecular hybridization techniques. Blood samples will be collected for all cases and controls and analyzed for evidence of prior exposure to sexually transmitted viral infections (a sample of blood will be stored for analysis when a test for HPV becomes available).

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA042792-01A1
Application #
3939034
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
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Hardikar, Sheetal; Johnson, Lisa G; Malkki, Mari et al. (2015) A population-based case-control study of genetic variation in cytokine genes associated with risk of cervical and vulvar cancers. Gynecol Oncol 139:90-6
Wallace, Nicholas A; Robinson, Kristin; Howie, Heather L et al. (2015) ?-HPV 5 and 8 E6 disrupt homology dependent double strand break repair by attenuating BRCA1 and BRCA2 expression and foci formation. PLoS Pathog 11:e1004687
Galloway, Denise A; Laimins, Laimonis A (2015) Human papillomaviruses: shared and distinct pathways for pathogenesis. Curr Opin Virol 14:87-92
Safaeian, Mahboobeh; Johnson, Lisa G; Yu, Kai et al. (2014) Human Leukocyte Antigen Class I and II Alleles and Cervical Adenocarcinoma. Front Oncol 4:119
Madeleine, Margaret M; Carter, Joseph J; Johnson, Lisa G et al. (2014) Risk of squamous cell skin cancer after organ transplant associated with antibodies to cutaneous papillomaviruses, polyomaviruses, and TMC6/8 (EVER1/2) variants. Cancer Med 3:1440-7
Wallace, Nicholas A; Galloway, Denise A (2014) Manipulation of cellular DNA damage repair machinery facilitates propagation of human papillomaviruses. Semin Cancer Biol 26:30-42

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