Contemporary successful management of patients with head and neck cancer often results in deformity and functional disability. This proposal intends to study the effects of single and multimodality cancer therapy and selected rehabilitation outcomes. Specifically, the program addresses consequences of cytotoxic therapy, deglutition, pulmonary and masticatory functions and nutritional/immunological effects. The research program is divided into five component projects. Project 5 studies the cardiac and renal problems that can result in chemotherapy. Methods of prevention and treatment are to be considered. Project 2 evaluates the effects of cancer and cancer treatment on swallowing strategies. Project 6 analyzes pulmonary function and aspiration and deterioration of status over time. Project 3 on mastication, relates masticatory function to cancer and its treatment. The effects of prostheses and osseous integrated implants are to be studied. Project 4 evaluates alterations in nutritional status, specifically zinc deficiency and how it relates to the immune condition of the patient. The design of the program provides ample opportunity to characterize the patient population and determine the effects of cancer therapy upon specific disabilities. Cross study correlates should add information regarding the effects of one or several variables upon each other. The outcomes should be new databases that can be used effectively in the planning of cancer treatment and the rehabilitation of the patient.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program Projects (P01)
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Special Emphasis Panel (SRC (A1))
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Wayne State University
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Meleca, R; Ahmad, S; Hamlet, S et al. (1999) Watching aspiration after radiation therapy. Otolaryngol Head Neck Surg 120:551-3
Doerr, T D; Marks, S C; Shamsa, F H et al. (1998) Effects of zinc and nutritional status on clinical outcomes in head and neck cancer. Nutrition 14:489-95
Prasad, A S; Beck, F W; Doerr, T D et al. (1998) Nutritional and zinc status of head and neck cancer patients: an interpretive review. J Am Coll Nutr 17:409-18
Hamlet, S; Faull, J; Klein, B et al. (1997) Mastication and swallowing in patients with postirradiation xerostomia. Int J Radiat Oncol Biol Phys 37:789-96
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Prasad, A S; Beck, F W; Grabowski, S M et al. (1997) Zinc deficiency: changes in cytokine production and T-cell subpopulations in patients with head and neck cancer and in noncancer subjects. Proc Assoc Am Physicians 109:68-77
Beck, F W; Kaplan, J; Fine, N et al. (1997) Decreased expression of CD73 (ecto-5'-nucleotidase) in the CD8+ subset is associated with zinc deficiency in human patients. J Lab Clin Med 130:147-56
Doerr, T D; Prasad, A S; Marks, S C et al. (1997) Zinc deficiency in head and neck cancer patients. J Am Coll Nutr 16:418-22
Prasad, A S; Kaplan, J; Beck, F W et al. (1997) Trace elements in head and neck cancer patients: zinc status and immunologic functions. Otolaryngol Head Neck Surg 116:624-9
Prasad, A S; Mantzoros, C S; Beck, F W et al. (1996) Zinc status and serum testosterone levels of healthy adults. Nutrition 12:344-8

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