Abstract

The overall objective of this proposal is to develop a better understanding of the basic mechanisms of action of Photodynamic Therapy (PDT). The program is an integration of research activities at Henry Ford Hospital, Wayne State University and Oakland University and a direct extension of other ongoing research collaborations in the area of PDT. The project consists of two cores and four separate proposals. The cores are to support overall administrative functions and for biostatistical support of all four projects. Project 1 proposes to investigate parameters for the effectiveness of PDT in primary tumors in pet animals. Project 2 plans to investigate the possibility of combining PDT with another new treatment modality, hyperthermia, which has at least one physiological response mechanism in common with PDT. Normal tissue response to PDT, in particular brain, will be studied in Project 3. Finally, Project 4 proposes to compare PDT with conventional illumination to illumination by chemiluminescence. Ultimately, these studies will provide a better understanding of the underlying mechanisms involved in PDT.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA043892-03
Application #
3094092
Study Section
(SRC)
Project Start
1987-09-01
Project End
1991-08-31
Budget Start
1989-09-01
Budget End
1991-08-31
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Henry Ford Health System
Department
Type
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202

  Publications

Wang, Luo-Wei; Huang, Zheng; Lin, Han et al. (2013) Effect of Photofrin-mediated photocytotoxicity on a panel of human pancreatic cancer cells. Photodiagnosis Photodyn Ther 10:244-251
Lei, Tim C; Pendyala, Srinivas; Scherrer, Larry et al. (2013) Optical profiles of cathode ray tube and liquid crystal display monitors: implication in cutaneous phototoxicity in photodynamic therapy. Appl Opt 52:2711-7
Weston, Mark A; Patterson, Michael S (2011) Calculation of singlet oxygen dose using explicit and implicit dose metrics during benzoporphyrin derivative monoacid ring A (BPD-MA)-PDT in vitro and correlation with MLL cell survival. Photochem Photobiol 87:1129-37
Santra, Manoranjan; Zheng, Xuguang; Roberts, Cindi et al. (2010) Single doublecortin gene therapy significantly reduces glioma tumor volume. J Neurosci Res 88:304-14
Singh, Gurmit; Alqawi, Omar; Espiritu, Myrna (2010) Metronomic PDT and cell death pathways. Methods Mol Biol 635:65-78
Zheng, Xuguang; Jiang, Feng; Katakowski, Mark et al. (2009) ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation. Cancer Biol Ther 8:1045-54
Hong, Xin; Jiang, Feng; Kalkanis, Steven N et al. (2009) Intracellular free calcium mediates glioma cell detachment and cytotoxicity after photodynamic therapy. Lasers Med Sci 24:777-86
Santra, Manoranjan; Santra, Sutapa; Roberts, Cindi et al. (2009) Doublecortin induces mitotic microtubule catastrophe and inhibits glioma cell invasion. J Neurochem 108:231-45
Gullo, Francesca; Maffezzoli, Andrea; Dossi, Elena et al. (2009) Short-latency cross- and autocorrelation identify clusters of interacting cortical neurons recorded from multi-electrode array. J Neurosci Methods 181:186-98
Szalad, Alexandra; Katakowski, Mark; Zheng, Xuguang et al. (2009) Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia. J Exp Clin Cancer Res 28:129

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