Abstract

This Program Project will continue to investigate Photodynamic Therapy (PDT). The five projects will cover research topics ranging from cellular resistance to PDT to clinical trials for the treatment of brain tumors. The projects are supported by two core activities which are integral to their successful conduct. The synergy of the Program will continue to depend upon the effective interactions between both the scientific projects and the investigators. Project 1 proposes to investigate, in vivo, possible methods to improve the effectiveness of PDT by increasing availability of oxygen in the tumor at the time of treatment. Project 2 proposes clinical trials of PDT for the treatment of malignant brain tumors. Two trials involving Photofrin, one for de novo and one for recurrent lesions, are planned. Project 3 will continue to investigate cellular resistance to PDT. Knowledge regarding the mechanisms by which such resistance develops is critical to the understanding of PDT at the cellular level. Project 4 will continue to investigate PDT dosimetry. The studies proposed in this project will have a direct impact on the clinical application of PDT. Project 5 will continue its in vivo studies examining PDT effects in brain tumor and normal brain. One area of focus will be to investigate alternate methods of drug delivery. Core will provide overall technical support for the program. Calibration of devices and interproject quality assurance will be provided by this core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA043892-12
Application #
6341900
Study Section
Subcommittee G - Education (NCI)
Program Officer
Stone, Helen B
Project Start
1998-03-16
Project End
2002-12-31
Budget Start
2001-01-01
Budget End
2001-12-31
Support Year
12
Fiscal Year
2001
Total Cost
$1,127,690
Indirect Cost

  Institution

Name
Healthone Alliance
Department
Type
DUNS #
098407869
City
Denver
State
CO
Country
United States
Zip Code
80203

  Publications

Wang, Luo-Wei; Huang, Zheng; Lin, Han et al. (2013) Effect of Photofrin-mediated photocytotoxicity on a panel of human pancreatic cancer cells. Photodiagnosis Photodyn Ther 10:244-251
Lei, Tim C; Pendyala, Srinivas; Scherrer, Larry et al. (2013) Optical profiles of cathode ray tube and liquid crystal display monitors: implication in cutaneous phototoxicity in photodynamic therapy. Appl Opt 52:2711-7
Weston, Mark A; Patterson, Michael S (2011) Calculation of singlet oxygen dose using explicit and implicit dose metrics during benzoporphyrin derivative monoacid ring A (BPD-MA)-PDT in vitro and correlation with MLL cell survival. Photochem Photobiol 87:1129-37
Santra, Manoranjan; Zheng, Xuguang; Roberts, Cindi et al. (2010) Single doublecortin gene therapy significantly reduces glioma tumor volume. J Neurosci Res 88:304-14
Singh, Gurmit; Alqawi, Omar; Espiritu, Myrna (2010) Metronomic PDT and cell death pathways. Methods Mol Biol 635:65-78
Weston, Mark A; Patterson, Michael S (2009) Simple photodynamic therapy dose models fail to predict the survival of MLL cells after HPPH-PDT in vitro. Photochem Photobiol 85:750-9
Zheng, Xuguang; Jiang, Feng; Katakowski, Mark et al. (2009) ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation. Cancer Biol Ther 8:1045-54
Hong, Xin; Jiang, Feng; Kalkanis, Steven N et al. (2009) Intracellular free calcium mediates glioma cell detachment and cytotoxicity after photodynamic therapy. Lasers Med Sci 24:777-86
Santra, Manoranjan; Santra, Sutapa; Roberts, Cindi et al. (2009) Doublecortin induces mitotic microtubule catastrophe and inhibits glioma cell invasion. J Neurochem 108:231-45
Gullo, Francesca; Maffezzoli, Andrea; Dossi, Elena et al. (2009) Short-latency cross- and autocorrelation identify clusters of interacting cortical neurons recorded from multi-electrode array. J Neurosci Methods 181:186-98

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