Core D Core Director: ColCher, David Principal Investigator: RaubitSChek. AndrewDESCRIPTION:Core D is the Animal Core: Pharmacokinetics, Imaging and Therapy. This core's main function is to supportthe quality control studies in animal models of the clinical reagents used in Project 1, the development of thetumor targeted radiolabeled constructs developed in Project 2 and the antibody based immunotherapeuticsin Project 3 in a number of model systems. The agents will be evaluated in both biodistribution and therapystudies as well as by using the advanced animal imaging instrumentation available at the COH, whereappropriate. The specific functions are: 1) To provide the needed facilities and expertise for evaluating thebiodistribution and imaging of antibody based constructs in small animals; and 2) To perform studies toanalyze the pharmacokinetics and therapeutic efficacy of antibody based radiolabeled constructs andimmunotherapeutics in model systems. The Core will also evaluate materials prepared in Core C for clinicaluse in Projects 1 and 3.Core D is a critical component of Projects 1, 2 and 3. All antibody constructs will be evaluated in vitro and invivo prior to translation into the clinic. The in vivo analysis will be performed as part of this Core using theexpertise of the Core's personnel. Animal biodistribution and imaging studies will be performed using theCore personnel with help as needed from the individual projects. The in vivo studies will require approval bythe Research Animal Care Committee and will be performed in the City of Hope Animal Resource Center inthe Pan/in building. This Core will evaluate the multi-step targeting methods, peptide linkers and novelantibody chelate conjugates developed in Project 2 after labeling with fl1ln, 1251,1311,1'l_u, 90Y, ^Cu,or 124I.
Showing the most recent 10 out of 112 publications
