Abstract

The Pathology component serves all of the projects and enables tumor diagnosis, detection of tissue antigens and a variety of other pathological techniques to be used in a uniform manner throughout the program. This allows a valid exchange of data among investigators based on the same morphological criteria. This component also provides carefully characterized tissue specimens for the investigators for analyses that are essential to the outcome of this program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA044704-09
Application #
6236890
Study Section
Project Start
1997-03-07
Project End
1998-01-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
9
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Lee, Y J; Galoforo, S S; Battle, P et al. (2001) Replicating adenoviral vector-mediated transfer of a heat-inducible double suicide gene for gene therapy. Cancer Gene Ther 8:397-404
Lotz, M M; Rabinovitz, I; Mercurio, A M (2000) Intestinal restitution: progression of actin cytoskeleton rearrangements and integrin function in a model of epithelial wound healing. Am J Pathol 156:985-96
Bachelder, R E; Marchetti, A; Falcioni, R et al. (1999) Activation of p53 function in carcinoma cells by the alpha6beta4 integrin. J Biol Chem 274:20733-7
Jessup, J M; Ishii, S; Mitzoi, T et al. (1999) Carcinoembryonic antigen facilitates experimental metastasis through a mechanism that does not involve adhesion to liver cells. Clin Exp Metastasis 17:481-8
Jessup, J M; Battle, P; Waller, H et al. (1999) Reactive nitrogen and oxygen radicals formed during hepatic ischemia-reperfusion kill weakly metastatic colorectal cancer cells. Cancer Res 59:1825-9
Rabinovitz, I; Toker, A; Mercurio, A M (1999) Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells. J Cell Biol 146:1147-60
Walsh, S; Murphy, M; Silverman, M et al. (1999) p27 expression in inflammatory bowel disease-associated neoplasia. Further evidence of a unique molecular pathogenesis. Am J Pathol 155:1511-8
Pories, S E; Hess, D T; Swenson, K et al. (1998) Overexpression of pp60c-src elicits invasive behavior in rat colon epithelial cells. Gastroenterology 114:1287-95
Jessup, J M (1998) Tumor markers--prognostic and therapeutic implications for colorectal carcinoma. Surg Oncol 7:139-51
Jessup, J M; Loda, M (1998) Prognostic markers in rectal carcinoma. Semin Surg Oncol 15:131-40

Showing the most recent 10 out of 143 publications