Abstract

The goal of these studies is to develop new genetic markers for predicting prognosis of breast cancer. It will: 1) utilize subtractive hybridization to find new genes; and 2) further evaluate the significance of an allelic loss at chromosome 1q23-32, first described by this project, with the long- term goal of cloning a putative suppressor gene at this locus. It will also measure the frequency of allelic losses at random genetic loci and/or amplifications to test the hypothesis that the likelihood of a specific genetic alteration conferring aggressive tumor behavior is directly proportional to the overall frequency of genetic aberrations in that tumor. It will examine breast cancers for evidence of aberrant methylation to determine whether abnormal methylation is associated with allelic instability. For selected breast cancer specimens, normal cells (either blood or skin) will be available from the patient and both parents. In these cases, studies will be performed to evaluate the role of maternal imprinting in breast cancer by determining whether the maternal allele is preferentially lost.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA044768-09
Application #
3750941
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
California Pacific Medical Center Research Institute
Department
Type
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94107

  Publications

Hwang, E Shelley; DeVries, Sandy; Chew, Karen L et al. (2004) Patterns of chromosomal alterations in breast ductal carcinoma in situ. Clin Cancer Res 10:5160-7
Shelley Hwang, E; Nyante, Sarah J; Yi Chen, Yunn et al. (2004) Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinoma. Cancer 100:2562-72
Gupta, Anu; Yang, Li Xi; Chen, Ling chun (2002) Study of the G2/M cell cycle checkpoint in irradiated mammary epithelial cells overexpressing Cul-4A gene. Int J Radiat Oncol Biol Phys 52:822-30
Neve, Richard M; Ylstra, Bauke; Chang, Chuan-Hsiung et al. (2002) ErbB2 activation of ESX gene expression. Oncogene 21:3934-8
Thor, Ann D; Eng, Clarence; Devries, Sandy et al. (2002) Invasive micropapillary carcinoma of the breast is associated with chromosome 8 abnormalities detected by comparative genomic hybridization. Hum Pathol 33:628-31
Eppenberger-Castori, S; Kueng, W; Benz, C et al. (2001) Prognostic and predictive significance of ErbB-2 breast tumor levels measured by enzyme immunoassay. J Clin Oncol 19:645-56
Gong, G; DeVries, S; Chew, K L et al. (2001) Genetic changes in paired atypical and usual ductal hyperplasia of the breast by comparative genomic hybridization. Clin Cancer Res 7:2410-4
Etzell, J E; Devries, S; Chew, K et al. (2001) Loss of chromosome 16q in lobular carcinoma in situ. Hum Pathol 32:292-6
Liu, S; Edgerton, S M; Moore 2nd, D H et al. (2001) Measures of cell turnover (proliferation and apoptosis) and their association with survival in breast cancer. Clin Cancer Res 7:1716-23
Waldman, F M; Hwang, E S; Etzell, J et al. (2001) Genomic alterations in tubular breast carcinomas. Hum Pathol 32:222-6

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