Abstract

The Clinical Program Core will provide tissue material from surgically excised specimens from women with primary breast cancer. The tissue will include a portion of the tumor, benign appearing breast tissue, skin and, when available, metastatic disease in lymph nodes. Special care will be taken to utilize tissue in an optimal way so that small tumors (~1 cm in diameter) can be included in the study without jeopardizing morphologic diagnosis. This will be achieved by using optimal dissection techniques and continuous updating of the tissue needs of the various research projects. The core will do the initial processing, including in vitro BrdUrd incorporation for study of proliferation and distribution of tissue to the projects. Patients suitable for the in vivo BrdUrd protocol will be identified, prepared, and administered the drug. Blood from patients with breast cancer, and from their parents, when feasible and possible, will be taken for cytogenetic studies. The clinical core will also conduct detailed histologic analyses of all cases and enter the resulting data into the database.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA044768-11
Application #
5207402
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Hwang, E Shelley; DeVries, Sandy; Chew, Karen L et al. (2004) Patterns of chromosomal alterations in breast ductal carcinoma in situ. Clin Cancer Res 10:5160-7
Shelley Hwang, E; Nyante, Sarah J; Yi Chen, Yunn et al. (2004) Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinoma. Cancer 100:2562-72
Gupta, Anu; Yang, Li Xi; Chen, Ling chun (2002) Study of the G2/M cell cycle checkpoint in irradiated mammary epithelial cells overexpressing Cul-4A gene. Int J Radiat Oncol Biol Phys 52:822-30
Neve, Richard M; Ylstra, Bauke; Chang, Chuan-Hsiung et al. (2002) ErbB2 activation of ESX gene expression. Oncogene 21:3934-8
Thor, Ann D; Eng, Clarence; Devries, Sandy et al. (2002) Invasive micropapillary carcinoma of the breast is associated with chromosome 8 abnormalities detected by comparative genomic hybridization. Hum Pathol 33:628-31
Eppenberger-Castori, S; Kueng, W; Benz, C et al. (2001) Prognostic and predictive significance of ErbB-2 breast tumor levels measured by enzyme immunoassay. J Clin Oncol 19:645-56
Gong, G; DeVries, S; Chew, K L et al. (2001) Genetic changes in paired atypical and usual ductal hyperplasia of the breast by comparative genomic hybridization. Clin Cancer Res 7:2410-4
Etzell, J E; Devries, S; Chew, K et al. (2001) Loss of chromosome 16q in lobular carcinoma in situ. Hum Pathol 32:292-6
Liu, S; Edgerton, S M; Moore 2nd, D H et al. (2001) Measures of cell turnover (proliferation and apoptosis) and their association with survival in breast cancer. Clin Cancer Res 7:1716-23
Waldman, F M; Hwang, E S; Etzell, J et al. (2001) Genomic alterations in tubular breast carcinomas. Hum Pathol 32:222-6

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